Iowa Fluoride Study/Iowa Bone Development Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1,882
- 主要终点
- bone densitometry-11
研究概览
简要总结
A cohort of newborns was recruited for the Iowa Fluoride Study from 1992-95 to assess the complex relationships among fluoride intakes, fluoride exposures, dental fluorosis, and dental caries. Detailed questionnaires were sent every 1.5-6 months concerning water sources, fluoride exposures, dietary intakes, etc. Standardized dental exams were conducted at ~ages 5, 9, 13, 17, and 23. At about age 5, participants were invited to join the offshoot Iowa Bone Development Study. Bone densitometry assessments were conducted at ages 5, 8, 11, 13, 15, 17, 19, and 23. These included Dual-energy X-ray Absorptiometry (DXA) of hip, lumbar spine, and whole body from age 5; peripheral Quantitative Computed Tomography (pQCT) of the radius and tibia from age 11; and Multi-Detector Computed Tomography (MDCT) of the tibia from age 19. Physical activity and other factors also were assessed longitudinally.
详细描述
A cohort of newborns was recruited for the Iowa Fluoride Study from 1992-95 to assess the complex relationships among fluoride intakes, fluoride exposures, dental fluorosis, and dental caries. Detailed questionnaires were sent every 1.5-6 months concerning water sources, fluoride exposures, dietary intakes, etc. Standardized dental exams were conducted at ~ages 5, 9, 13, 17, and 23. At about age 5, participants were invited to join the offshoot Iowa Bone Development Study. Bone densitometry assessments were conducted at ages 5, 8, 11, 13, 15, 17, 19, and 23. These included Dual-energy X-ray Absorptiometry (DXA) of hip, lumbar spine, and whole body from age 5; peripheral Quantitative Computed Tomography (pQCT) of the radius and tibia from age 11; and Multi-Detector Computed Tomography (MDCT) of the tibia from age 19. Physical activity and other factors also were assessed longitudinally.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Month 至 30 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy newborn
排除标准
- •not health newborn
结局指标
主要结局
bone densitometry-11
时间窗: age 11
DXA and pQCT scans
dental fluorosis-5
时间窗: age 5
dental fluorosis exam results
dental fluorosis-9
时间窗: age 9
dental fluorosis exam results
dental fluorosis-17
时间窗: age 17
dental fluorosis exam results
dental fluorosis-23
时间窗: age 23
dental fluorosis exam results
dental fluorosis-13
时间窗: age 13
dental fluorosis exam results
dental caries-9
时间窗: age 5
dental caries exam results
dental caries-5
时间窗: age 5
dental caries exam results
dental caries-23
时间窗: age 23
dental caries exam results
bone densitometry-13
时间窗: age 13
DXA and pQCT scans
dental caries-13
时间窗: age 9
dental caries exam results
bone densitometry-8
时间窗: age 8
DXA scans
dental caries-17
时间窗: age 17
dental caries exam results
bone densitometry-5
时间窗: age 5
DXA scans
bone densitometry-15
时间窗: age 15
DXA and pQCT scans
bone densitometry-17
时间窗: age 17
DXA and pQCT scans
bone densitometry-19
时间窗: age 19
DXA, pQCT, and MDCT scans
bone densitometry-23
时间窗: age 23
DXA, pQCT, and MDCT scans
次要结局
未报告次要终点
研究者
Steven M Levy
Professor
University of Iowa