Functional Magnetic Resonance Imaging (fMRI) Analysis of Aging and Awareness in Conditioning
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 16
- 主要终点
- CS-US Awareness
研究概览
简要总结
Cathodal Transcranial direct current stimulation (tDCS) was administered to the right parietal region in order to determine if this stimulation could disrupt awareness of the conditioned stimulus (CS) - unconditioned stimulus (US) relationship in a classical conditioning experiment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Educational attainment of at least eight years and English as the native language
- •Mini-Mental State Examination (MMSE) score of 26
- •Normal episodic memory (i.e., CERAD word List Recall > 5)
- •Informed consent; 5) age of 20-30
排除标准
- •Disturbed consciousness
- •Other neurological or systemic disorder which can cause dementia or cognitive dysfunction
- •Prior history of a major psychiatric disorder
- •History of definite stroke
- •Focal lesion on MRI exam
- •Use of anxiolytic, antidepressant, neuroleptic, or sedative medication
- •Predominately left-handed
- •Has MRI contraindication such as pacemaker, implanted pumps, shrapnel, etc. (full MRI screening form will be filled out).
结局指标
主要结局
CS-US Awareness
时间窗: recorded immediately after the 20 minutes of tDCS stimulation
To assess CS-US awareness, we used a questionnaire The questionnaire consists of 7 true/false questions about the sequence and co-occurrence of the conditioned stimulus (CS, a 1000 Hz tone) and unconditioned stimulus (US, a 100 ms puff of air to the eye). The score can thus range from 0 to 7. Higher score values indicate better awareness of the sequence and co-occurrence of the CS and US
次要结局
- Line bisection test of left-hemifield neglect(recorded immediately after primary awareness questionnaire)
- Eyeblink conditioned responding(recorded during the tDCS administration)