Prospective Characterization of the Heart, Aorta and Blood Pressure in Women With Turner Syndrome. Association With Aortic Dissection.
试验速览
- 阶段
- 不适用
- 入组人数
- 106
- 试验地点
- 1
- 主要终点
- Aortic dimensions
研究概览
简要总结
Turner syndrome is a congenital complete or partial lack one of the female sex chromosomes affecting 1 of 2000 live born girls. The syndrome is characterized by an increased prevalence of ischemic heart disease, aortic dilation and dissection, hypertension, stroke and autoimmune diseases in general.
Our study aim is:
- Using MRI to further characterize and find risk factors leading to aortic dilation.
- Using MRI to assess the degree of aortic distensibility.
- Using Computed tomography x-ray scanning of the heart and coronary arteries to characterize the prevalence and degree of ischemic heart disease and coronary anomalies.
- Using pressure sensitive ultrasound (applanation tonometry) to assess the degree of aortic stiffness when compared to controls using end points as Pulse Wave Velocity, Augmentation Index and Central Pulse Pressure.
详细描述
Turner syndrome is a congenital complete or partial lack one of the female sex chromosomes affecting 1 of 2000 live born girls. The syndrome is characterized by an increased prevalence of ischemic heart disease, aortic dilation and dissection, congenital heart defects, hypertension, stroke, ovarian failure, infertility, decreased final height and autoimmune diseases in general
Our study aim is:
- Using MRI to further characterize and find risk factors leading to aortic dilation.
- Using MRI to describe aortic dimensions
- Using MRI to assess the degree of aortic distensibility.
- Using Computed tomography x-ray scanning of the heart and coronary arteries to characterize the prevalence and degree of ischemic heart disease and coronary anomalies.
- Using pressure sensitive ultrasound (applanation tonometry) to assess the degree of aortic stiffness when compared to controls using end points as Pulse Wave Velocity, Augmentation Index and Central Pulse Pressure.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •Contraindications for MRI
- •Contraindications for CT
- •Severe obesity
- •Acute og Chronic disease with known or presumed significance with concern to outcomes of the study
- •Previous or present malignant disease
- •Clinically significant liver disease
- •Mechanic or biological heart valves
结局指标
主要结局
Aortic dimensions
时间窗: Once
Aortic dimensions measured by MRI
Agatston score
时间窗: Once
Coronary CT evaluation of Agatston score
Segment involvement score
时间窗: Once
Segment involvement score (SIS) calculated as the sum of segments with one or more coronary plaques (score 0-18).
Aortic distensibility
时间窗: Once
Aortic distensibillity as measured by MRI
次要结局
- 24 hour blood pressure(24 hour)
- Pulse Wave Velocity(Once)
- Augmentation index(Once)
- Central blood pressure(Once)