The pathogenesis of vaginal dryness in women with primary Sjögren*s syndrome: a pilot study - Vaginal dryness in primary Sjögren's syndrome

niversitair Medisch Centrum Groningen0 个研究点目标入组 20 人开始时间: 待定最近更新: 2024年2月28日

适应症

试验速览

暂无简介。

•Diagnosis of pSS according to the American European Consensus Group (AECG) classification criteria.
•Presence of vaginal sicca symptoms ;All participants:
•Female gender
•Age >=18
•Premenopausal status according to the World Health Organisation definition.
•Written informed consent

•Presence of other systemic autoimmune disease
•Use of systemische corticosteroids within 1 month before inclusion.
•Use of disease modifying anti-rheumatic drugs (DMARDs), except hydroxychloroquine, within 1 month before inclusion.
•Use of biological DMARDs within 6 months before inclusion.
•Use of hormone replacement therapy or use of vaginal oestrogen supplementation
•Use of a intrauterine contraceptive device
•Pregnancy
•Presence of a known infectious or non-infectious inflammatory disorder of the vagina or cervix (e.g. lichen sclerosis or lichen planus of the vagina, sexually transmitted infections)
•Other gynaecological or non-gynaecological comorbidity which is expected to influence the vaginal or cervical health and/or gynaecological immune markers according to the investigators, including previous chemotherapy.

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