Effect of the Neuromodulation of the Cervical Spinal Cord on Nociceptive Processing in Healthy Volunteers - a Randomized, Double-blinded Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- Change in contact-heat evoked potentials amplitude
研究概览
简要总结
Several studies have demonstrated that direct currents delivered through the skin at the level of the lumbar spinal cord can influence spinal cord function. In human volunteers, anodal lumbar transcutaneous spinal direct current stimulation (tsDCS) alters spinal processing of nociceptive inputs. Whether cervical tsDCS is able to do the same is less well known.
详细描述
The investigators will compare the effects on the nociceptive processing of healthy volunteers of cervical and lumbar tsDCS. This study will be a double-blinded, sham-controlled, cross-over trial. Each participant will undergo two experimental sessions (anodal cervical tsDCS and sham lumbar tsDCS vs. sham cervical tsDCS and anodal lumbar tsDCS), separated by at least one week.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy young adults
排除标准
- •Known medical conditions (e.g., diabetes, neuropathy, psychiatric disorders, seizure, migraine, pacemaker or other implanted medical devices...)
- •Use of any medication (except contraception)
结局指标
主要结局
Change in contact-heat evoked potentials amplitude
时间窗: Change from Baseline, at 15-minutes after the end of stimulation
N2/P2 amplitude
次要结局
- Change in temporal summation of pain(Change from Baseline, at 15-minutes after the end of stimulation)
- Change in intensity of perception to mechanical pinprick nociceptive stimuli(Change from Baseline, at 15-minutes after the end of stimulation)
- Change in intensity of perception to contact-heat nociceptive stimuli(Change from Baseline, at 15-minutes after the end of stimulation)