NCT04436848Unknown不适用
Identifying Leucocyte and Urine Biomarkers in Parkinson's Patients With LRRK2 G2385R Gene Variant
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Identification of monocyte-based biomarkers for LRRK2 G2385R variant
研究概览
简要总结
Given the emerging evidence on LRRK2-related biomarkers, this project will focus on identifying leucocyte and urine biomarkers that are altered by the LRRK2 G2385R variant, and investigating the effects of LRRK2 kinase inhibitor (MLi-2) on these biomarkers, using immunoblotting and mass spectrometry.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Diagnosis of Parkinson's disease assigned by a movement disorder specialist according to clinical diagnostic criteria
- •Age above 18 year-old
- •Provision of a written informed consent
排除标准
- •Physical or mental incapacity to complete study protocol
结局指标
主要结局
Identification of monocyte-based biomarkers for LRRK2 G2385R variant
时间窗: Two years
Identification of urine-based biomarkers for LRRK2 G2385R variant
时间窗: Two years
次要结局
未报告次要终点
研究者
研究点 (1)
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