Common and Distinct Mechanisms of Expectancy Effects Across Outcomes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- Within Participant Subjective Ratings of Acute Thermal Pain Following High Compared to Low Cues (Learned Via Instructions Only)
研究概览
简要总结
A behavioral study that will examine how pain perception is affected by different types of conditioning and by context, with a few participants and multiple sessions ("N-of-few" design).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 55 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy participants
排除标准
- •Cannot tolerate heat pain applied to the forearm/leg, based on a calibration task at the beginning of the experiment
结局指标
主要结局
Within Participant Subjective Ratings of Acute Thermal Pain Following High Compared to Low Cues (Learned Via Instructions Only)
时间窗: Measured repeatedly during pain tasks, in each of the 10 sessions of the experiment (up to 3 sessions per week, depending on the participants' availability), immediately after thermal stimuli. Averaged across sessions and compared across conditions.
Each session of the experiment includes pain tasks, in which multiple thermal stimuli are delivered. Following each thermal stimulus, participants are asked to rate how painful it was, on a semi-circular computerized scale. Ratings are based on the angle (0-180), with higher angle representing higher pain ratings. In the instructions only condition, cues are learned via verbal suggestion. For the cues that were learned via instructions only, the investigators will compare the average rating of pain for stimuli that are preceded by high cues minus the average rating of pain for stimuli that are preceded by low cues (each averaged across sessions), within participant.
Within Participant Subjective Ratings of Acute Thermal Pain, When it is the Worse vs. the Better Alternative
时间窗: Measured repeatedly during pain tasks, in each of the last 4 sessions of the experiment, immediately after thermal stimuli. Averaged across sessions and compared across conditions.
In the counterfactual task, participants are presented with two alternatives (either two pain levels, or one pain level and either losing or gaining a certain amount of money). In these pairs of alternatives, the medium level pain is sometimes the better option (i.e., when the alternative is losing money or a more intense pain stimulus) and sometimes the worse option (i.e., when the other alternative is gaining money or a less intense pain stimulus). One of the two options is chosen by the computer (participants have no control on this choice). The investigators will compare the pain ratings (scale 0-180) within participant for the same level pain stimulus (medium intensity) when it is the worse vs. the better option.
Within Participant Subjective Ratings of Acute Thermal Pain Following High Compared to Low Cues (Learned Via Conditioning)
时间窗: Measured repeatedly during pain tasks, in each of the 10 sessions of the experiment (up to 3 sessions per week, depending on the participants' availability), immediately after thermal stimuli. Averaged across sessions and compared across conditions.
Each session of the experiment includes pain tasks, in which multiple thermal stimuli are delivered. Following each thermal stimulus, participants are asked to rate how painful it was, on a semi-circular computerized scale. Ratings are based on the angle (0-180), with higher angle representing higher pain ratings. In the conditioning procedure, cues are conditioned to different temperatures by delivering thermal stimuli with different temperatures after cues are presented (higher temperature following high cues and lower temperature following low cues). For the cues that were learned via conditioning, the investigators will compare the average rating of pain for stimuli that are preceded by high cues minus the average rating of pain for stimuli that are preceded by low cues (each averaged across sessions), within participant.
Within Participant Subjective Ratings of Acute Thermal Pain Following High Compared to Low Cues (Learned Via Symbolic Learning)
时间窗: Measured repeatedly during pain tasks, in each of the 10 sessions of the experiment (up to 3 sessions per week, depending on the participants' availability), immediately after thermal stimuli. Averaged across sessions and compared across conditions.
Each session of the experiment includes pain tasks, in which multiple thermal stimuli are delivered. Following each thermal stimulus, participants are asked to rate how painful it was, on a semi-circular computerized scale. Ratings are based on the angle (0-180), with higher angle representing higher pain ratings. In the symbolic learning procedure, cues are conditioned to different temperatures based on pictures of thermometers (instead of actual thermal stimuli as in the conditioning procedure). For the cues that were learned via symbolic learning, the investigators will compare the average rating of pain for stimuli that are preceded by high cues minus the average rating of pain for stimuli that are preceded by low cues (each averaged across sessions), within participant.
次要结局
未报告次要终点
研究者
Tor Wager
Diana L. Taylor Distinguished Professor
Trustees of Dartmouth College
