A Retrospective Study of Treatment Patterns and Clinical Outcomes in Patients With Central Nervous System Tuberculosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 638
- 试验地点
- 2
- 主要终点
- 2-year survival rate
研究概览
简要总结
This is a retrospective clinical study to analyze the clinical characteristics, complications, and effects of different treatment options on long-term prognosis in patients with central nervous system tuberculosis. All cases of central nervous system tuberculosis diagnosed between 2016 and 2021 were included in the electronic medical record system of one center, and data such as demographics, hospitalization information, clinical information, laboratory or imaging examinations, treatment plans, and outcomes were collected.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The patient meets the following criteria 1) or 2) or 3):
- •The discharge diagnosis is central nervous system tuberculosis, refer to the ICD-10 code related to central nervous system tuberculosis.
- •The discharge diagnosis was tuberculous meningitis (ICD-10: A17.000), or tuberculous cerebrospinal meningitis (ICD-10: A17.001), or tuberculous meningoencephalitis (ICD-10: A17.803 ), or tuberculous encephalitis (ICD-10: A17.804), or tuberculous brain abscess (ICD-10: A17.805), or spinal tuberculosis (ICD-10: A17.806), or tuberculous encephalitis Water (ICD-10: A17.807).
- •Tuberculous meningitis diagnosed according to the "Guidelines for Diagnosis and Treatment of Central Nervous System Tuberculosis in China (2019 Edition)"
- •Age and gender are not limited.
排除标准
- •Patients with no clear diagnosis at discharge.
- •Patients judged by the investigator to be unsuitable for inclusion in this protocol.
结局指标
主要结局
2-year survival rate
时间窗: 1 years,2 years
Calculate the 1-year survival rate and 2-year survival rate.
2-year disability rate
时间窗: 1 years,2 years
Calculate the 1-year disability rate and 2-year disability rate. Common disabilities include aphasia, hemiplegia, paraplegia, deafness, blindness, mental retardation, etc. For reference, please refer to the 《Grading of Human Injury and Disability Degree》 and 《Guidance for determination of cause-and-effect relationship between personal injury and disease》.
次要结局
- length of hospital stay(2 years)
- proportion of patients admitted to ICU(2 years)
- Clinical features: age of onset, mode of onset(2 years)
- The presense of clinical symptoms of patients(2 years)
- Incidence of complications in patients with different treatment regimens(2 years)
研究者
Qin Ning
Director and Chair of Department of Infectious Diseases
Tongji Hospital