Individually Optimized Contrast-Enhancement 4D-CT for Pancreatic Adenocarcinoma in Radiotherapy Simulation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 14
- 试验地点
- 1
- 主要终点
- Individually Optimized Contrast-enhanced 4DCT for Radiotherapy Simulation
研究概览
简要总结
The primary objective is to study the feasibility and efficacy of individually optimized CE 4D-CT for PDA in radiotherapy simulation.
详细描述
Compared with current clinical practice, the individually optimized CE 4D-CT can potentially provide much improved tumor-to-parenchyma conspicuity of pancreatic adenocarcinoma. This will help the radiation oncologists or radiologists to contour the tumor with higher precision and confidence, and compute the tumor volume and tumor motion more accurately.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients 18 years old or older
- •Patients with PDA who have not had surgical removal of their tumor and who are planned for treatment with radiotherapy in the Radiation Oncology Department at the University of Maryland.
- •Patients who have signed the contrast consent form and have been recommended by physicians to have contrast-enhanced CT scans.
- •Patients who have signed the consent form for this study
排除标准
- •Pregnant or breast-feeding women.
- •Patients with severely decreased renal function19-
- •Patients with known severe allergic reactions to contrast.
- •Patients who have difficulty lying flat on their back for extended periods of time.
- •Patients with breaths per minute (BPM) rate less than 10, due to the limitation of 4D-CT image reconstruction software.
结局指标
主要结局
Individually Optimized Contrast-enhanced 4DCT for Radiotherapy Simulation
时间窗: 1 year
Image quality (anatomic details, motion artifacts, beam hardening and enhancement of pancreatic tissue and tumor were scored from 1 to 5, with 1 being very poor and 5 being excellent), CT number of pancreas and tumor, tumor-to-pancreas contrast, image noise and contrast-to-noise ration (CNR) were compared among contrast-enhanced (CE) 4DCT, CE 3DCT and 4DCT without contrast enhancement.
次要结局
未报告次要终点
研究者
Department of Radiation Oncology
Assistant Professor, Physics
University of Maryland, Baltimore