Smartphone App-guided Inspiratory Muscle Strength Training for Lowering Systolic Blood Pressure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 33
- 试验地点
- 1
- 主要终点
- Change from baseline in casual systolic blood pressure
研究概览
简要总结
This clinical trial aims to assess the efficacy of inspiratory muscle strength training (IMST) guided by a smartphone app vs. IMST delivered in a clinical research setting for lowering systolic blood pressure in adults 18 years and older with elevated blood pressure. Participants will perform IMST for 5 minutes a day, 6 days a week, for 6 weeks.
详细描述
Having above-normal blood pressure, i.e., ≥120 mmHg systolic blood pressure (SBP) and/or ≥80 mmHg diastolic blood pressure (DBP), increases risk of developing cardiovascular diseases, cognitive decline/dementia, chronic kidney disease, and other chronic health problems. Approximately 60% of all US adults have above-normal BP, primarily driven by above-normal SBP.
Currently, above-normal SBP is the single largest modifiable risk factor for cardiovascular mortality in the United States. Thus, developing novel strategies for lowering SBP is an urgent public health and biomedical research priority.
Guidelines emphasize regular aerobic exercise as a first-line intervention for all stages of above-normal systolic blood pressure (SBP). Current guidelines call for ≥150 minutes of aerobic activity per week. However, only ~50% of US adults meet these aerobic exercise guidelines. The greatest reported barrier to achieving aerobic exercise guidelines is lack of time. High-resistance inspiratory muscle strength training (IMST) is a time-efficient (5 minutes per session) lifestyle intervention consisting of 30 inspiratory maneuvers performed against a high resistance. Preliminary data suggest 6-weeks of IMST performed 6 days/week reduces SBP by 9 mmHg in adults with above-normal SBP (i.e., greater than 120 mmHg) at baseline. Importantly, this reduction in SBP is equal to or greater than the reduction in blood pressure typically achieved with time- and effort-intensive healthy lifestyle strategies like conventional aerobic exercise.
The investigators hope utilizing a smartphone app to guide IMST will promote the translation of IMST for widespread use and improving public health. The investigators will conduct a randomized, controlled, single-blind, parallel group design clinical trial to assess the efficacy of 6-weeks of IMST (55%-75% maximal inspiratory pressure) delivered in the research clinic by the study investigators vs. IMST delivered entirely via a smartphone app without investigator involvement, for lowering resting and home SBP in adults aged 18 years and older with above-normal SBP (120-160 mmHg) at baseline. The investigators will also assess the effect of IMST on endothelial function, large-elastic artery stiffness, and potential mechanisms of action.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18+ years
- •Ability to provide informed consent
- •Willing to accept random assignment to condition
- •Systolic blood pressure 120-160 mmHg
- •Owns an Apple or Android smartphone
- •Body mass index <40 kg/m2
- •Subject report of being weight stable in the prior 3 months (<2 kg weight change) and willing to remain weight stable during the 6-week intervention period
- •Subjects taking antihypertensive medications will be included provided they meet the other inclusion criteria, including systolic blood pressure. Medication regimen (prescription and dosing) must be stable for at least 3 months prior to enrollment in the study and must remain stable during the 6-week intervention period. These medications will not be withheld prior to experimental protocols.
- •If woman of childbearing age:
- •Not pregnant (defined as self-report of pregnancy)
- •Willing to be abstinent or use approved contraception (i.e., hormonal contraception, intrauterine devices, barrier methods such as condoms with spermicide, and surgical sterilization) throughout the duration of the study
排除标准
- •Age <18 years
- •Participant report of a chronic overt medical condition (e.g., unstable cardiovascular disease, recent myocardial infarction or stroke, cancer) that may make it unsafe to participate in the study under the discretion of the study Medical Director.
- •Inability to abstain from consumption of alcohol for 12 hours on experimental days.
- •Report of blood donation within 8 weeks prior to enrolling in the study or unwillingness to abstain from donating blood for 8 weeks after completing the study
- •Participant report of current ruptured eardrum or any other current condition of the ear
- •Participant report of recent abdominal surgery (past 3 months) or current abdominal hernia
- •Participant report of current asthma with very low symptom perception, frequent and severe exacerbations, or abnormally low perception of dyspnea
- •Participant report of past or current costochondritis (inflammation of the cartilage that joins the ribs to the breastbone)
研究组 & 干预措施
App-Based Inspiratory Muscle Strength Training
Using a handheld device, participants will perform 30 breaths a day, six days a week, for six weeks. Training will be guided by a smartphone application.
干预措施: App-Based Inspiratory Muscle Strength Training (Device)
Clinic-Based Inspiratory Muscle Strength Training
Using a handheld device, participants will perform 30 breaths a day, six days a week, for six weeks. Training will be guided by researchers.
干预措施: Clinic-Based Inspiratory Muscle Strength Training (Device)
结局指标
主要结局
Change from baseline in casual systolic blood pressure
时间窗: 6 weeks
Systolic blood pressure at rest in the clinic setting
Change from baseline in home systolic blood pressure
时间窗: 6 weeks
Systolic blood pressure measured at rest in the home
Change From Baseline in Casual Systolic Blood Pressure
时间窗: 6 weeks
Change in systolic blood pressure at rest in the clinic setting
Change From Baseline in Home Systolic Blood Pressure
时间窗: 6 weeks
Change in systolic blood pressure measured at rest in the home
次要结局
- Difference in adherence to IMST(6 weeks)
- Change from baseline in maximum inspiratory pressure(6 weeks)
- Change from baseline in endothelial function(6 weeks)
- Change From Baseline in Endothelial Function(6 weeks)
- Change From Baseline in Maximum Inspiratory Pressure(6 weeks)
- Difference in Adherence to Inspiratory Muscle Strength Training(6 weeks)
研究者
Douglas Seals
Distinguished Professor
University of Colorado, Boulder