Biomarkers, Hemodynamic and Echocardiographic Predictors of Ischemic Strokes and Their Influence on the Course and Prognosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 主要终点
- physiological parameter
研究概览
简要总结
A stroke is the second cause of deaths after heart attack, one of the most important causes of malfunction as far as adults are concerned and the second as for the frequency cause of dementia. In spite of a possibility of the therapy of stroke ( tissue plasminogen activator) and recognized most of risk factors there is expected that incidence rate on stroke connected with ageing of the society will be growing. It will cause medical and social consequences.
There are many of potential causes of cardiac strokes, which are not entirely examined.
More over many cryptogenic strokes are presumed to have an embolic etiology, and the frequent cause of these kind of strokes at young age is probably the mechanism of paradoxical embolism through patent foramen ovale.
As far as the investigators are concerned, at present there is lack of any recommendations for these scientific hypothesis.
详细描述
A stroke is the second cause of deaths after heart attack, one of the most important causes of malfunction as far as adults are concerned and the second as for the frequency cause of dementia. In spite of a possibility of the therapy of stroke ( tissue plasminogen activator) and recognized most of risk factors there is expected that incidence rate on stroke connected with ageing of the society will be growing. It will cause medical and social consequences.
The risk factors of stroke can be divided into alterable and not alterable. Importantly, the not alterable factors are: age, sex, race and genetic factors. After the age of 55 the risk of stroke grows twice in every decade of life. Moreover, it was alleged that incidence rate on stroke is more frequent at women than at men. At the black race the incidence rate on stroke is twice more frequent than at white race.
Well- known are also genetic syndromes connected with strokes like s. MELAS or CADASIL.
Well- known alterable factors are:
- hypertension
- coronary disease
- atrial fibrillation
- hypercholesterolemia
- diabetes
- nicotinism
- blood clotting disorder
- alcoholism
- TIA (transient ischemic attack) or previous former stroke
- asymptomatic stenosis of internal carotid artery
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •stroke of undetermined cause
排除标准
- •unstable hypertension
- •atrial fibrillation
- •hyperthyroidism hard
- •pregnancy and breastfeeding
- •autoimmunologic disease
- •active infection
- •incapable of giving agreement
研究组 & 干预措施
Experimental Group
Patients with stroke of undetermined cause age 18-65
干预措施: ADMA (asymmetric dimethylarginine) , NTproBNP (N-terminal pro b-type natriuretic peptide), IL-6 (Interleukin 6), Adiponectina, Leptine, Syndecan, Resistin (Diagnostic Test)
Comparative group
Healthy patients age 18-65
干预措施: ADMA (asymmetric dimethylarginine) , NTproBNP (N-terminal pro b-type natriuretic peptide), IL-6 (Interleukin 6), Adiponectina, Leptine, Syndecan, Resistin (Diagnostic Test)
结局指标
主要结局
physiological parameter
时间窗: 24 months
CRP (C reactive protein)
次要结局
未报告次要终点
研究者
Paulina Gąsiorek
Principal Investigator
Medical University of Lodz