RESISTANCE TRAINING AND CAPILLARIZATION - ROLE ON THE ANABOLIC RESPONSE IN OLDER ADULTS
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- muscle hypertrophy
研究概览
简要总结
The goal of this clinical trial is to learn how muscle capillaries influence the response to resistance exercise training in older adults. The study will include older men and women who may experience age-related declines in muscle mass and function. The main questions it aims to answer are:
- Does baseline muscle capillarization influence the increase in muscle size and function following resistance exercise training?
- Can resistance exercise stimulate the formation of new capillaries in older adults with lower baseline capillarization, and how is this related to muscle growth?
Participants will:
- Undergo assessments of muscle structure, capillarization, and physical function before and after the intervention.
- Participate in a supervised resistance exercise training program.
- Provide muscle samples and other physiological measurements to evaluate changes in muscle growth and blood vessel formation.
Researchers will analyze the relationship between baseline muscle capillarization, exercise-induced angiogenesis, and improvements in muscle mass and function to better understand why some older adults respond more effectively to resistance exercise than others.
详细描述
This randomized clinical trial will investigate the effects of different exercise training strategies on skeletal muscle adaptations in older adults. Participants will be randomly assigned to one of three training groups and will complete a supervised 12-week exercise program, consisting of three sessions per week.
The interventions will include different combinations and sequencing of resistance and aerobic exercise during the first 8 weeks of training, followed by a standardized resistance training program during the final 4 weeks. The study is designed to determine whether the timing and type of exercise influence muscle growth, vascular adaptations, and functional outcomes.
Participants will undergo assessments before the intervention and after 4, 8, and 12 weeks of training. Measurements will include body composition, muscle size and architecture, muscle strength, aerobic fitness, and physical function. A subgroup of participants may also undergo optional muscle biopsies to evaluate changes in muscle capillarization and biological markers associated with muscle adaptation.
The results will help identify exercise strategies that optimize muscle and vascular adaptations in older adults and improve understanding of the mechanisms underlying individual variability in training responsiveness.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age ≥ 65 years
- •Body Mass Index (BMI) >18 and <30 kg/m²
- •Stable body weight for at least 3 months prior to enrollment
排除标准
- •Prediabetes or diabetes according to ADA criteria
- •Chronic diseases, including cardiovascular, liver, respiratory diseases, or cancer
- •Acute inflammatory conditions, infections, or other clinically significant illnesses
- •Regular participation in vigorous physical activity (≥2 sessions per week)
- •Current or recent (within the previous 3 months) treatment with steroid medications
- •Regular use of protein supplements
研究组 & 干预措施
RRR
Effect of 3 months of progressive resistance training on muscle adaptation in older adults
干预措施: Exercise (Other)
ARR
Effect of 1 month of aerobic training followed by 2 months of progressive resistance training on muscle adaptation in older adults
干预措施: Exercise (Other)
RAR
Effect of the combination of 1 month of resistance training followed by 1 month of aerobic training and 1 months of progressive resistance training on muscle adaptation in older adults
干预措施: Exercise (Other)
结局指标
主要结局
muscle hypertrophy
时间窗: 3 months
difference of kilograms of Lean Body Mass from baseline measured by DEXA
capillary density
时间窗: 3 month
change on the number of capillary per muscle fiber measured histochemically trought muscle biopsy.
次要结局
未报告次要终点