The Impact of Hepatitis B Virus Infection on the Clinical Course of Inflammatory Bowel Disease in Egyptian Patients
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 162
- 试验地点
- 1
- 主要终点
- Number of patients with severe IBD measured by Truelove-Witts severity index
研究概览
简要总结
The goal of this observational retrospective study is to assess the impact of hepatitis B virus (HBV) infection on the clinical course and outcomes of inflammatory bowel disease (IBD) in Egyptian patients.
Researchers will compare the IBD extent, location, severity, and behavior between IBD patients with and without HBV infection.
Participants will be subjected to history-taking (history of hospital admission and disease flare, surgical history, medication history, follow-up duration, and mortality), clinical examination, laboratory investigations, abdominal ultrasonography, and endoscopic examination.
研究设计
- 研究类型
- Observational
- 观察模型
- Ecologic Or Community
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or female patients older than 18 years.
- •Patients with IBD are diagnosed by clinical, radiological, endoscopic, and histological criteria.
排除标准
- •Patients aged < 18 years
- •Unwilling to participate in our study
结局指标
主要结局
Number of patients with severe IBD measured by Truelove-Witts severity index
时间窗: through study completion, an average of 6 month
comparing IBD extent, location, and behavior using Montreal classification, Truelove-Witts severity index between patients with and without HBV infection
Hospital admission rates in IBD patients
时间窗: through study completion, an average of 6 month
comparing IBD hospital admission rates between patients with and without HBV infection
number of IBD patients undergoing surgical treatment
时间窗: through study completion, an average of 6 month
comparing surgical treatment rates (intestinal resection in CD patients and total proctocolectomy in UC patients) for IBD between patients with and without HBV infection
次要结局
- Disease flares rates in IBD patients(through study completion, an average of 6 months)
- mortality rates in IBD patients(through study completion, an average of 6 months)
研究者
Rania Mamdouh Elkafoury
Lecturer of Tropical Medicine
Tanta University