Posterior Macular Adhesion: A Potential Risk Factor for Non-exudative AMD to Develop Exudative AMD
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 320
- 试验地点
- 1
- 主要终点
- Number of eyes with non-exudative AMD with attached and detached posterior vitreous cortex developing exudative AMD
研究概览
简要总结
Choroidal neovascularisation in age related macular degeneration is one of the major causes of legal blindness in the western world existing in two major occurences, the dry and the wet form.The etiology of age related macular degeneration is yet unknown. Genetic factors, oxidative stress, Ischaemia, and aging of the retinal pigment epithelium are discussed as etiologic factors. The risk of rapid vision loss is much higher in wet AMD, a dry form may transform to a wet form. From a prior study the investigators know that the posterior hyaloid is significantly more frequent attached in wet AMD. This study is conducted to examine whether the attached posterior hyaloid is a risk factor to develop wet AMD in dry AMD cases.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age over 50 years
排除标准
- •Macular pathologies other than age related macular degeneration (like diabetic maculopathy, macular pucker, macular hole)
- •Prior vitrectomy or buckle surgery
- •Uveitis posterior, multifocal chorioiditis
- •Pathologic myopia
- •Diabetic retinopathy
- •Visualization of the macula not possible (dens cataract, vitreous haemorrhage)
结局指标
主要结局
Number of eyes with non-exudative AMD with attached and detached posterior vitreous cortex developing exudative AMD
时间窗: 24 months
次要结局
- Distance acuity(24 months)
- Age(24 months)
- Smoking(24 months)
- Obesity(24 months)
- Lesion classification (AREDS)(24 months)