Propofol cardioprotection during ischaemia-reperfusion to preserve myocardial function: an interventional randomised efficacy study

niversity of British Columbia (Canada)0 个研究点目标入组 144 人开始时间: 2010年3月11日最近更新: 2016年10月17日

试验速览

暂无简介。

•1. Adult patients aged 18 - 80 years, either sex
•2. Undergoing primary coronary artery bypass graft (CABG) surgery requiring cardiopulmonary bypass (CPB) at the Vancouver General Hospital
•3. Require revascularisation of three or more coronary arteries with an anticipated aortic cross-clamp time of at least 60 minutes
•4. Have a pre-operative systolic blood pressure above 90 mmHg in the absence of inotropic or mechanical support

•1. Type I diabetes mellitus (defined as an established history and diagnosis of diabetes mellitus requiring insulin therapy from the time of diagnosis)
•2. Co-existing valvular heart disease (moderate to severe aortic stenosis or mitral regurgitation)
•3. Acute or evolving myocardial infarction
•4. History of hypersensitivity to propofol or any of its formulation components
•5. Taking non-steroidal anti-inflammatory drugs, vitamin C, or vitamin E within five days of surgery

发起方

niversity of British Columbia (Canada)