JPRN-UMIN000005216已完成2 期
Randomized phase II trial of FOLFIRI with either panitumumab or bevacizumab as second-line treatment in patients with KRAS wild metastatic colorectal cancer refractory to oxaliplatin and bevacizumab with exploratory analysis to predict treatment efficacy and prognosis - FOLFIRI+Pmab vs FOLFIRI+BV as second-line for colorectal cancer
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 200
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 20years-old 至 ot applicable（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •1) previous history of chemotherapy including irinotecan, cetuximab, or panitumumab 2) symptomatic brain metastasis or brain metastasis with under medication 3) intestinal obstruction 4) uncontrollable ascites or pleural effusion 5) uncontrollable diarrhea 6) having other active malignancies 7) having active infections 8) pulmonary fibrosis or interstitial pneumonia 9) serious comorbidities, such as uncontrollable diabetes mellitus, severe heart disease (NYHA>III), renal failure, and liver failure 10) History of arterial thromboembolic events such as unstable angia, myocardial infarction, brain hemorrhage, and brain infarction within 6 months. 11) having wound healing problem (excluding central venous port) 12) History of major surgery within 28 days or 14 days after colostomy. 13) Meningitis carcinomatosis or uncontrollable seizures, serious mental problem or neurologic disorders 14) continuous steroid administration 15) serious drug allergy 16) HIV infection 17) Pregnant or lactating female 18) Other serious medical conditions.
研究者
相似试验
进行中（未招募）
1 期
Comparison of chemotherapy with radiochemotherapy as treatment of patients with locally advanced, primarily inoperable pancreatic carcinomalocally advanced, primarily inoperable pancreatic carcinomaEUCTR2012-001850-24-ATABCSG (Austrian Breast & Colorectal Cancer Study Group)112
进行中（未招募）
1 期
Evaluation of the efficacy of a combinaison treatment based upon immunotherapy + chemotherapy to treat patient with a stomach cancerAdvanced gastric or gastro-oesophageal junction adenocarcinomaMedDRA version: 20.0 Level: LLT Classification code 10042080 Term: Stomach cancer System Organ Class: 100000004864MedDRA version: 20.0 Level: LLT Classification code 10026476 Term: Malignant neoplasm of stomach System Organ Class: 100000004864EUCTR2018-002014-13-FRFédération Francophone de Cancérologie Digestive94
进行中（未招募）
不适用
A randomized phase II study of FOLFORI plus or not CETUXIMAB in elderly advanced colorectal cancer patients.Elderly mestatic colorectal cancer patients, Wild-type KRAS ,70-80 years of age, ECOG 0-1.MedDRA version: 14.1Level: SOCClassification code 10029104Term: Neoplasms benign, malignant and unspecified (incl cysts and polyps)System Organ Class: 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)EUCTR2012-000477-23-ITAZIENDA OSPEDALIERO UNIVERSITARIA OSPEDALI RIUNITI UMBERTO I - G.M.LANCISI - G.SALESI
已完成
2 期
Randomized phase II study of FOLFIRI plus ramucirumab versus FOLFOXIRI plus ramucirumab as first-line treatment in patients with metastatic colorectal cancer(WJOG9216G)first-line treatment in patients with metastatic colorectal cancerJPRN-UMIN000026527West Japan Oncology Group120
进行中（未招募）
2 期
Randomized phase II study of FOLFIRI plus ramucirumab versus FOLFOXIRI plus ramucirumab as first-line treatment in patients with metastatic colorectal cancer (WJOG9216G)JPRN-jRCTs041180166Kito Yosuke120