The Benefit of Autologous Blood Transfusion in Total Hip Arthroplasty
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 75
- 主要终点
- Patient red blood cells value
研究概览
简要总结
The investigators studied the benefit of preoperative autologous blood donation in participants who undergo total hip arthroplasty. Study is made as a prospective and randomized.
详细描述
Total hip arthroplasty is procedure followed with large perioperative and postoperative blood loss. In order to avoid the application of large amounts of allogeneic blood, preoperative autologous blood donation as a tipe of autologous transfusion have been developed.
In this study, the investigators studied the benefit of preoperative autologous blood donation in participants who undergo total hip arthroplasty. Study is made as a prospective and randomized.
Participants were divided into three groups: the first group donated one dose of autologous blood 14 days preoperatively, the second group donated one dose of autologous blood 72 hours preoperatively and a third group was not donated autologous blood.
The blood parameters, hemodynamic stability, bleeding, the need for application of autologous or homologous blood and length of hospital stay were compared.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •subject older than 18 years
- •subject has primary coxarthrosis
- •subject has indication for total hip replacement
排除标准
- •subject has secondary coxarthrosis
- •subject has need for revision endoprosthesis
- •history of autoimmune, malignancy or coagulation disorder
- •history of myocardial infarct or cerebrovascular insult in last 6 months
- •history of angina pectoris and unregulated hypertension
- •history of renal or liver failure
结局指标
主要结局
Patient red blood cells value
时间窗: 6 days
analysis of blood sample day before surgery, 3 hours after surgery, on first, second, fifth postoperative day and on sixth postoperative day
Patient hematocrit value
时间窗: 6 days
analysis of blood sample day before surgery, 3 hours after surgery, on first, second, fifth postoperative day and on sixth postoperative day
Need for autologous blood transfusion
时间窗: 6 days
Based on blood count and hemodynamic stability
Need for homologous blood transfusion
时间窗: 6 days
Based on blood count and hemodynamic stability
Patient hemoglobin value
时间窗: 6 days
analysis of blood sample day before surgery, 3 hours after surgery, on first, second, fifth postoperative day and on sixth postoperative day
次要结局
- Length of hospital stay(6 days)
研究者
Zrinka Oreskovic
Principal investigator
Clinical Hospital Centre Zagreb