Role of Immunotherapy in the Treatment of Eyelid Viral Papilloma
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 2
- 主要终点
- complete response
研究概览
简要总结
intralesional injection of Candida antigens for treating eyelid warts is supposed to have less destructive effect than other surgical interventions
详细描述
Despite many surgical and interventional modalities of treating ocular warts, all have a destructive nature for this delicate tissue with a high recurrence rate. intralesional injection of Candida antigens was suggested to be an effective and safe treatment for such a condition aim: Providing safe and effective treatment of ocular wart. objective:
- To determine the efficacy of intralesional injection of Candida antigens in the treatment of eyelids wart
- To determine the safety of intralesional injection of Candida antigens in the treatment of eyelids wart
- To report complications of intralesional injection of Candida antigens in the treatment of eyelids wart
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 12 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with cutaneous eyelid viral warts whether single or multiple, with no concurrent systemic or topical treatment for warts. Patients aged more than 12 years, with sensitivity test, showed induration less than or equal to five mm. and patients can understand and comply with the requirements of the trials.
排除标准
- •pregnancy, breastfeeding, patients with immunodeficiency; like diabetics. In addition, patients with a history of hypersensitivity to any used component in this trial, asthma, or allergic skin diseases. Moreover, patients on any treatment modality for warts at least 1 month before the start of the study.
结局指标
主要结局
complete response
时间窗: after maximum 6 treatment sessions of intralesional injection with 2 weeks between the successive sessions
to report the complete response defined by the efficacy of intralesional injection of Candida antigen in achieving complete disappearance of eyelid warts and return to normal skin
次要结局
- partial response(after maximum 6 treatment sessions of intralesional injection with 2 weeks between the successive sessions)
- Failure(after maximum 6 treatment sessions of intralesional injection with 2 weeks between the successive sessions)
- complications(after maximum 6 treatment sessions of intralesional injection with 2 weeks between the successive sessions)
研究者
Marwa Ahmed Khairy Elsayed Essa
Principle investigator, lecturer of ophthalmology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Zagazig University