The Effects of Early vs. Delayed Time-Restricted Eating on Metabolic Syndrome Parameters in Obese Women: A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- Change in Body Weight (kg)
研究概览
简要总结
This study aims to compare the effects of early and delayed time-restricted eating on metabolic syndrome parameters in obese women.
详细描述
This randomized controlled trial investigates the effects of time-restricted eating with different timing windows on metabolic syndrome parameters. A total of 36 sedentary obese women aged between 20-49 years were randomly assigned to one of three groups: Early Time-Restricted Eating (eTRE; 08:00-16:00), Delayed Time-Restricted Eating (dTRE; 12:00-20:00), and a Control group (08:00-20:00). Participants' physical activity levels were assessed using a one-day physical activity log. Total energy expenditure was calculated, and a 25% energy restriction was applied to create individualized medical nutrition therapy. Anthropometric measurements, body composition, and biochemical parameters were collected before and after the 8-week intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 49 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •BMI > 30 kg/m²
- •Able to follow dietary protocols
- •No chronic disease (T1DM, T2DM, cardiovascular disease, cancer)
- •Not on a weight loss diet in the past 6 months
- •No psychiatric disorder
- •Sedentary lifestyle
排除标准
- •Menopausal women
- •Cardiovascular disease
- •Type 1 or Type 2 Diabetes
- •Use of weight loss medications
- •Pregnant or breastfeeding
- •Shift workers
研究组 & 干预措施
Early Time-Restricted Eating with Calorie Restriction
Participants ate all meals between 08:00 and 16:00 daily with calorie restriction diet for 8 weeks.
干预措施: Early time restricted eating with calorie restriction (Behavioral)
Delayed Time-Restricted Eating with Calorie Restriction
Participants ate all meals between 12:00 and 20:00 daily with calorie restriction diet for 8 weeks.
干预措施: Delayed Time Restricted Eating with calorie restriction (Behavioral)
control
Participants ate all meals between 08:00 and 20:00 daily with calorie restriction diet for 8 weeks.
干预措施: Control group with calorie restriction (Behavioral)
结局指标
主要结局
Change in Body Weight (kg)
时间窗: from enrollment to the end of treatment at 8 weeks
Body weight will be measured in kilograms using standardized procedures at baseline and at the end of the 8-week intervention.
Change in Body Mass Index (BMI) (kg/m²)
时间窗: from enrollment to the end of treatment at 8 weeks
Body Mass Index (BMI), calculated as weight (kg) divided by height squared (m²), will be recorded at baseline and at the end of the 8-week intervention.
Change in Waist Circumference (cm)
时间窗: from enrollment to the end of treatment at 8 weeks
Waist circumference will be measured in centimeters at baseline and at the end of the 8-week intervention using standardized anthropometric procedures.
Change in Body Weight (kg)
时间窗: from enrollment to the end of treatment at 8 weeks
Body weight will be measured in kilograms using standardized procedures at baseline and at the end of the 8-week intervention.
Change in Body Mass Index (BMI) (kg/m²)
时间窗: from enrollment to the end of treatment at 8 weeks
Body Mass Index (BMI), calculated as weight (kg) divided by height squared (m²), will be recorded at baseline and at the end of the 8-week intervention.
Change in Waist Circumference (cm)
时间窗: from enrollment to the end of treatment at 8 weeks
Waist circumference will be measured in centimeters at baseline and at the end of the 8-week intervention using standardized anthropometric procedures.
次要结局
- Change in HOMA-IR(From enrollment to the end of the treatment at 8 weeks)
- Change in Fasting Glucose (mg/dL)(From enrollment to the end of the treatment at 8 weeks)
- Change in Fasting Insulin (μIU/mL)(From enrollment to the end of the treatment at 8 weeks)
- Change in HOMA-IR(From enrollment to the end of the treatment at 8 weeks)
- Change in Total Cholesterol (mg/dL)(From enrollment to the end of the treatment at 8 weeks)
- Change in Systolic and Diastolic Blood Pressure (mmHg)(From enrollment to the end of the treatment at 8 weeks)
- Change in LDL Cholesterol (mg/dL)(From enrollment to the end of the treatment at 8 weeks)
- Change in HDL Cholesterol (mg/dL)(From enrollment to the end of the treatment at 8 weeks)
- Change in Triglycerides (mg/dL)(From enrollment to the end of the treatment at 8 weeks)
- Change in Fasting Glucose (mg/dL)(From enrollment to the end of the treatment at 8 weeks)
- Change in Fasting Insulin (μIU/mL)(From enrollment to the end of the treatment at 8 weeks)
- Change in Total Cholesterol (mg/dL)(From enrollment to the end of the treatment at 8 weeks)
- Change in Systolic and Diastolic Blood Pressure (mmHg)(From enrollment to the end of the treatment at 8 weeks)
- Change in LDL Cholesterol (mg/dL)(From enrollment to the end of the treatment at 8 weeks)
- Change in HDL Cholesterol (mg/dL)(From enrollment to the end of the treatment at 8 weeks)
- Change in Triglycerides (mg/dL)(From enrollment to the end of the treatment at 8 weeks)
研究者
SINEM BAYRAM
Assoc. Prof.
Baskent University