NCT04530760招募中不适用
Impact of Intraabdominal Hypertension on Microaspiration Incidence in Cirrhotic Patients
University Hospital, Lille2 个研究点 分布在 1 个国家目标入组 226 人开始时间: 2021年10月8日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 226
- 试验地点
- 2
- 主要终点
- abundant microaspiration
研究概览
简要总结
The study aims to demonstrate the relationship between intra-abdominal hypertension (IAH) and abundant microaspirations in mechanically ventilated cirrhotic.
详细描述
Intra-abdominal pressure monitoring will be performed using intra-vesical pressure every 8 hour in the first 2 days of mechanical ventilation.
Micro aspiration is defined by pepsin or amylase positivity in trachea suction. Two groups will be compared : one with IAH , one without IAH.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •adult patients
- •Cirrhosis
- •intubation and mechanical ventilation
排除标准
- •pregnancy
- •oliguric patients
- •impossibility to measure intravesical pressure
结局指标
主要结局
abundant microaspiration
时间窗: 48 hours after inclusion
presence of pepsin or alpha amylase at significant level in at least 30% of tracheal aspirates
次要结局
- duration of mechanical ventilation(from intubation until day 28 or extubation)
- Incidence of ventilator associated pneumonia (VAP)(from intubation until day 28 or extubation)
- incidence of patients requiring renal replacement therapy(from ICU admission until Day 28 or ICu discharge, whichever came first)
- incidence of cirrhosis related complications(from ICU admission until Day 28 or ICU discharge, whichever came first)
- Mortality(from ICU admission until day 28)
研究者
研究点 (2)
Loading locations...
相似试验
已完成
不适用
The usefulness of assessing markers of severity among women with ovarian hyperstimulation syndromeOvarian hyperstimulation syndrome (OHSS)Nutritional, Metabolic, EndocrineISRCTN66235250Federal State Budgetary Institution Center for the Development of Education and International Activities (Inter-education”)76
尚未招募
不适用
Intra-abdominal Hypertension and Abdominal Compartment Syndrome in Patients After Pancreatic Procedures.Intra Abdominal PressurePancreatic SurgeryPancreatic Fistula After PancreaticoduodenectomyDelayed Gastric EmptyingAnastomotic LeaksOverload FluidAbdominal Compartment SyndromeNCT06672601Charles University, Czech Republic150
Unknown
不适用
Effect of the Intra-abdominal Pressure on the Risk of Delirium in Mechanically Ventilated Patients.Intraabdominal HypertensionMechanical Ventilation ComplicationDeliriumNCT03218358Assiut University100
已完成
不适用
Intra-abdominal hypertension and abdominal compartment syndrome in high risk patients admitted to the ICU: a prospective studyNL-OMON38488niversitair Medisch Centrum Groningen500
尚未招募
2 期
A study to compare two different treatment modalities to reduce the increased abdominal pressure that happens in patients with acute pancreatitisCTRI/2024/02/062750Dr. Jayanta samanta