Effect of Cocoa Supplementation in Training Athletes Microbiota and Metabolome: Effects on Acute and Adaptive Exercise
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Fecal metabolome profile
研究概览
简要总结
It has recently been suggested that cocoa may improve exercise performance and recovery. This study aim to evaluate the plasma and fecal metabolome after 10 weeks of cocoa supplementation during the training period in recreational athletes to detect possible metabolites involved in the observed benefits of cocoa in athletes
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •18-45 years of age
- •high physical condition (VO2 ≥ 55 ml/kg/min)
- •BMI 18-25 kg/m2
排除标准
- •antibiotics intake during 3 months prior to the study,
- •nutritional complements
- •ergogenic complements
- •prebiotics
- •probiotics
- •vegetarian or vegan diet
- •chronic medication
- •gastrointestinal surgery
- •Any diagnosed disease
结局指标
主要结局
Fecal metabolome profile
时间窗: Changes from baseline to 10 weeks of intervention
Abundance of fecal metabolites, metabolic networks, and metabolic pathways determined by High Pressure Liquid Chromatography-Mass Spectrometry
Plasma metabolome profile
时间窗: Changes from baseline to 10 weeks of intervention
Abundance of blood metabolites, metabolic networks, and metabolic pathways activity determined by High Pressure Liquid Chromatography-Mass Spectrometry
Fecal microbiota
时间窗: Changes from baseline to 10 weeks of intervention
Abundance of bacterial taxa determined by 16SRNAr gene sequencing
次要结局
未报告次要终点
研究者
Mar Larrosa
Tenure Professor
Universidad Europea de Madrid