Dietary Intervention to Stop Coronary Atherosclerosis in Computed Tomography: Long-Term Follow-Up
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 92
- 试验地点
- 1
- 主要终点
- Percent Atheroma Volume (PAV) (Change)
研究概览
简要总结
A long-term evaluation of the impact of intensive diet and lifestyle intervention on coronary plaque dynamics in patients with coronary atherosclerosis diagnosed in computed tomography angiography (CCTA).
92 patients who completed the Dietary Intervention to Stop COronary Atherosclerosis in Computed Tomography study (DISCO-CT, NCT02571803) will be followed-up.
详细描述
All patients who completed the Dietary Intervention to Stop COronary Atherosclerosis in Computed Tomography received dietary and lifestyle recommendations and were referred to outpatient specialist care at their place of residence.
As part of this study, patients will be invited for a follow-up visit consisting of a cardiological and dietician consultation and additional tests, including CCTA, to assess the long-term impact of the intervention on the progression of atherosclerotic plaques, including high-risk plaque component.
Additionally, the occurrence of cardiovascular events, change in laboratory parameters and change in body weight composition will be analyzed.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Percent Atheroma Volume (PAV) (Change)
时间窗: 60 months
Quantitative assessment of the coronary plaque dynamics will be analyzed in the coronary computed tomography angiography and compared with parameters measured at the completion of the DISCO-CT study (expressed in percent) PAV = \[(EEM-LA)/EEM\]\*100% EEM - external elastic membrane area LA - lumen area
Total Atheroma Volume (Change)
时间窗: 60 months
Quantitative assessment of the coronary plaque dynamics will be analyzed in the coronary computed tomography angiography and compared with parameters measured at the completion of the DISCO-CT study (expressed in mm3)
次要结局
- Calcified Plaque Volume (Change)(60 months)
- Rate of major cardiovascular events(60 months)
- Fibrous Plaque Volume (Change)(60 months)
- Fibrofatty Plaque Volume (Change)(60 months)
- Necrotic Core (Low Density) Plaque Volume (Change)(60 months)
- Non-Calcified Plaque Volume (Change)(60 months)