Cardiopulmonary Health Effects of Indoor Air Purification and Different Indoor Environmental Factors Among School Children in Beijing
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- Levels of lung function indicators
研究概览
简要总结
The objective of this study is to investigate the cardiopulmonary health effects of indoor air purification and different indoor environmental factors among school students in Beijing.
详细描述
This randomized, double-blind crossover study was conducted to explore the cardiopulmonary effects of ionization air purification among 48 children in Beijing. Real or sham purification was performed in classrooms for 5 weekdays in a random order with a 2-month wash-out period. During the study periods, different indoor environmental factors were monitored including size-fractionated particulate matter (PM), black carbon (BC), ozone, carbon dioxide (CO2), negative air ions (NAI), noise, temperature and relative humidity, which were controlled as confounders in the analysis of the effects of indoor air purification. In addition, we analyzed the cardiopulmonary effects of those environmental factors on the children.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 10 Years 至 14 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •living in Beijing for more than two consecutive years;
- •living in school dormitories from Monday to Friday.
排除标准
- •suffering any health condition;
- •having asthma or thoracic surgery history.
研究组 & 干预措施
Real purification
Air purifier turned on
干预措施: Air purifier (Other)
Sham purification
Air purifier turned off
干预措施: Air purifier (Other)
结局指标
主要结局
Levels of lung function indicators
时间窗: 10 weekdays for intervention (active or sham) and 2 wash-out months
Lung function test was conducted including forced expiratory volume in one second (FEV1) and peak expiratory flow (PEF).
次要结局
- Levels of urinary metabolomics(10 weekdays for intervention (active or sham) and 2 wash-out months)
- Changes in ST-segment elevation(10 weekdays for intervention (active or sham) and 2 wash-out months)
- Levels of oxidative stress in Exhaled Breath Condensate (EBC)(10 weekdays for intervention (active or sham) and 2 wash-out months)
- Changes in autonomic cardiac function(10 weekdays for intervention (active or sham) and 2 wash-out months)
- Level of respiratory inflammation(10 weekdays for intervention (active or sham) and 2 wash-out months)
研究者
Furong Deng
MD & PhD, Professor, Deputy Director of Department of Occupational & Environmental Health Sciences
Peking University