A Multicenter, Adaptive, Randomized, Blinded Controlled Trial of the Safety and Efficacy of Investigational Therapeutics for Hospitalized Patients With COVID-19
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 2,753
- 试验地点
- 135
- 主要终点
- Time from randomization to sustained recovery
研究概览
简要总结
This study looks at the safety and effectiveness of different drugs in treating COVID-19 in people who have been hospitalized with the infection. Participants in the study will be treated with either a study drug plus current standard of care (SOC), or with placebo plus current SOC.
详细描述
This is a master protocol to evaluate the safety and efficacy of multiple investigational agents aimed at modifying the host immune response to SARS-CoV-2 infection, or directly enhancing viral control in order to limit disease progression.
The protocol is for a randomized, blinded, controlled platform study that allows investigational drugs to be added and dropped during the course of the study. This allows for efficient testing of new drugs against placebo and standard of care (SOC) treatment within the same study. When more than one drug is being tested at the same time, participants will be randomly allocated to treatments or placebo.
Randomization will be stratified by study site pharmacy and disease severity. There are 2 disease severity strata: Participants without organ failure (severity stratum 1); and participants with organ failure (severity stratum 2).
An independent Data and Safety Monitoring Board (DSMB) will regularly review interim analyses and summarize safety and efficacy outcomes. For investigational drugs with minimal pre-existing safety knowledge, the pace of enrollment with be initially restricted, and there will be an early review of safety data by the DSMB. For the study of each agent, at the outset of the trial, only participants in disease severity stratum 1 will be enrolled. This will continue until approximately 300 participants are enrolled and followed for 5 days. The exact number will vary according to the speed of enrollment and the timing of DSMB meetings. Prior to expanding enrollment to also include patients in disease severity stratum 2, safety will be evaluated and a pre-specified futility assessment by the DSMB will be carried out using 2 ordinal outcomes assessed at Day 5.
Both ordinal outcomes are used to assess futility because it is currently unclear whether the investigational agents under study will primarily influence non-pulmonary outcomes, for which risk is increased with SARS-CoV-2 infection, in part, through mechanisms that may be different from those that influence pulmonary outcomes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Signed informed consent.
- •Positive test for COVID-19 and progressive disease suggestive of ongoing COVID-19 infection.
- •Symptoms of COVID-19 for ≤ 12 days.
- •Require admission to hospital for acute medical care (not for purely public health or quarantine purposes).
排除标准
- •Patients who have received plasma from a person who recovered from COVID-19 or who have received neutralizing monoclonal antibodies at any time prior to hospitalization.
- •Patients not willing to abstain from participation in other COVID-19 treatment trials until after Day 5 of the study. Co-enrollment in certain trials that compare recommended Standard of Care treatments may be allowed, based on the opinion of the study leadership team.
- •Any condition which, in the opinion of the responsible investigator, participation would not be in the best interest of the participant or that could prevent, limit, or confound the protocol-specified assessments.
- •Patients considered unable to participate in study procedures.
- •Women of child-bearing potential who are not already pregnant at study entry and who are unwilling to acknowledge strong advice to abstain from sexual intercourse with men or practice appropriate contraception through 18 months of the study.
- •Women of child-bearing potential who are unwilling to acknowledge the strong advice to abstain from sexual intercourse with men or practice appropriate contraception through 5 weeks of the study (PF-07304814 investigational agent).
- •Pregnant women (PF-07304814 investigational agents).
- •Nursing mothers (PF-07304814 investigational agents).
- •Men who are unwilling to acknowledge the strong advice to abstain from sexual intercourse with women of child-bearing potential or to use barrier contraception through 18 months of the study.
- •Men who are unwilling to acknowledge the strong advice to abstain from sexual intercourse with women of child-bearing potential or to use barrier contraception through 5 weeks of the study (PF-07304814 investigational agent).
- •Presence at study enrollment of any of the following:
- •encephalitis
- •myocardial ischemia
- •myocarditis
- •pericarditis
- •symptomatic congestive heart failure
- •arterial or deep venous thrombosis or pulmonary embolism
- •Current or imminent requirement for any of the following:
- •invasive mechanical ventilation
- •ECMO (extracorporeal membrane oxygenation)
- •Mechanical circulatory support
- •vasopressor therapy
- •commencement of renal replacement therapy at this admission (i.e. not patients on chronic renal replacement therapy).
- •Participants with moderate to severe hepatic impairment (i.e. Child-Pugh class B or C) or acute liver failure (PF-07304814 investigational agent).
- •Participants receiving any medications or substances that are strong inhibitors or inducers of cytochrome P450 (CYP) 3A4 (PF-07304814 investigational agent).
- •Patients will be excluded if taking drugs which have a narrow therapeutic window that are substrates of CYP3A4, including but not limited to: astemizole, cisapride, cyclosporine, dihydroergotamine, ergotamine, pimozide, quinidine, sirolimus, tacrolimus, and terfenadine (PF-07304814 investigational agent).
- •Patients with a history of deep vein thrombosis or pulmonary thrombotic embolism (Prior to initial futility assessment of PF-07304814 investigational agent).
研究组 & 干预措施
ACTIV-3 Drug plus SOC
Participants in this study will be randomized to receive one of the ACTIV-3 drug treatments plus Standard of Care (SOC) or placebo plus SOC
干预措施: LY3819253 (Biological)
ACTIV-3 Drug plus SOC
Participants in this study will be randomized to receive one of the ACTIV-3 drug treatments plus Standard of Care (SOC) or placebo plus SOC
干预措施: Remdesivir (Biological)
ACTIV-3 Drug plus SOC
Participants in this study will be randomized to receive one of the ACTIV-3 drug treatments plus Standard of Care (SOC) or placebo plus SOC
干预措施: VIR-7831 (Biological)
ACTIV-3 Drug plus SOC
Participants in this study will be randomized to receive one of the ACTIV-3 drug treatments plus Standard of Care (SOC) or placebo plus SOC
干预措施: BRII-196/BRII-198 (Biological)
ACTIV-3 Drug plus SOC
Participants in this study will be randomized to receive one of the ACTIV-3 drug treatments plus Standard of Care (SOC) or placebo plus SOC
干预措施: AZD7442 (Biological)
ACTIV-3 Drug plus SOC
Participants in this study will be randomized to receive one of the ACTIV-3 drug treatments plus Standard of Care (SOC) or placebo plus SOC
干预措施: MP0420 (Drug)
ACTIV-3 Drug plus SOC
Participants in this study will be randomized to receive one of the ACTIV-3 drug treatments plus Standard of Care (SOC) or placebo plus SOC
干预措施: PF-07304814 (Drug)
Placebo plus SOC
The placebo arm may be pooled across more than one experimental arm if multiple investigational drugs are available to be tested at the same time. If it is not possible to use matching placebo over more than one experimental arm, additional placebo arms will be included in the study
干预措施: Placebo (Drug)
Placebo plus SOC
The placebo arm may be pooled across more than one experimental arm if multiple investigational drugs are available to be tested at the same time. If it is not possible to use matching placebo over more than one experimental arm, additional placebo arms will be included in the study
干预措施: Remdesivir (Biological)
结局指标
主要结局
Time from randomization to sustained recovery
时间窗: Up to Day 90
Sustained recovery defined as being discharged from the index hospitalization, followed by being alive and home for 14 consecutive days prior to Day 90.
次要结局
- All-cause mortality(Thru Day 90)
- Composite of time to sustained recovery and mortality(Thru Day 90)
- Days alive outside short-term acute care hospital(Up to Day 90)
- Pulmonary ordinal outcome(Days 1-7, 14 and 28)
- Pulmonary+ ordinal outcome(Days 1-7)
- Incidence of clinical organ failure(Thru Day 28)
- Composite of death or serious clinical COVID-19 related events(Thru Day 90)
- Composite of cardiovascular events and thromboembolic events(Thru Day 90)
- Composite of grade 3 and 4 clinical adverse events, serious adverse events (SAEs) or death(Thru Days 5 and 28)
- Incidence of infusion reactions(Thru Day 0)
- Composite of SAEs or death(Thru 18 months)
- Change in SARS-CoV-2 neutralizing antibody levels(Baseline to Days 1, 3, 5, 28 and 90)
- Change in overall titers of antibodies(Baseline to Days 1, 3, 5, 28 and 90)
- Change in neutralizing antibody levels(Baseline to Days 1, 3, 5, 28 and 90)
- Incidence of home use of supplemental oxygen above pre-morbid oxygen use(18 months)
- Incidence of no home use of supplemental oxygen above pre-morbid oxygen use(14 days)