Modulation of Cognitive Flexibility by Transcranial Direct Current Stimulation, Tyrosine Administration and Polymorphisms in the COMT Gene
试验速览
- 阶段
- 不适用
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- Wisconsin Card Sorting Test (WCST) performance
研究概览
简要总结
The current study would examine whether increases in endogenous dopaminergic activity via tyrosine and the (presumed) excitation of these by anodal tDCS of the dlPFC could causally be related to cognitive flexibility as measured by task switching and reversal learning.
Additionally, the study will test whether the Val158Met-polymorphism in the catechol- O-methyltransferase (COMT) gene could also predict the effect of TYR supplementation, as this gene is involved in DA degradation in the prefrontal cortex.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •• Either male or female
- •Between 18 and 30 years
- •You are in good health
- •You agree to fast overnight prior to testing
排除标准
- •• Are suffering from cardiac, hepatic, renal, neurological disorders
- •Damaged or diseased skin on your face and scalp, or a sensitive scalp
- •A history of alcohol or drug addiction, or severe psychiatric illness
- •Drug treatment which may lower seizure threshold (i.e. epilepsy)
- •Pregnancy
- •Sleep deprivation (less than 6 hours a day)
- •A history of migraine or headaches
- •A history of taking antidepressants
- •A history of taking tyrosine supplements
研究组 & 干预措施
tDCS sham + placebo
tDCS= transcranial direct current stimulation drugs= placebo (cellulose [2 grams])
干预措施: tdcs (sham/anodal) + drug (placebo/tyrosine) (Combination Product)
tDCS sham + tyrosine
tDCS= transcranial direct current stimulation drugs= tyrosine (2 grams)
干预措施: tdcs (sham/anodal) + drug (placebo/tyrosine) (Combination Product)
tDCS anodal + placebo
tDCS= anodal transcranial direct current stimulation of the dorsolateral prefrontal cortex drugs= placebo (cellulose [2 grams])
干预措施: tdcs (sham/anodal) + drug (placebo/tyrosine) (Combination Product)
tDCS anodal +tyrosine
tDCS= anodal transcranial direct current stimulation of the dorsolateral prefrontal cortex drugs= tyrosine (2 grams)
干预措施: tdcs (sham/anodal) + drug (placebo/tyrosine) (Combination Product)
结局指标
主要结局
Wisconsin Card Sorting Test (WCST) performance
时间窗: Measured twice in each session (4 arms): at time 0 and 80 minutes into testing.
Measuring change in perseverative errors in the WCST
Probabilistic Reversal Learning (PRL) performance
时间窗: Measured twice in each session (4 arms): at time 0 and 80 minutes into testing.
Measuring change in reversal errors in the WCST
Flanker Task performance
时间窗: Measured twice in each session (4 arms): at time 0 and 80 minutes into testing.
Measuring change in conflict cost (defined as the difference in reaction time between congruent and incongruent responses)
次要结局
未报告次要终点