PICNIC Study - PatIent Centered aNtIbiotic Courses in Children With Medical Complexity
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Proportion of eligible patients who consent to participate in the intervention
研究概览
简要总结
To determine if clinicians can safely reduce antibiotic exposure in children with medical complexity (CMC) who are diagnosed with pneumonia by implementing an intervention that bases total antibiotic duration on an individual's clinical stability.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 2 Years 至 25 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Admitted to the Complex Care Service at Boston Children's Hospital with a provider diagnosis of pneumonia
- •Started on antibiotics by the provider team
- •Ages 2-25 years old
排除标准
- •Patients initially admitted to the intermediate care unit or ICU due to increased respiratory support needs
研究组 & 干预措施
Intervention Group
Patients will be started on antibiotics for treatment of pneumonia per usual care by their medical provider team. The research team will monitor enrolled patients daily for markers of their clinical status (caregiver assessment of respiratory status, supplemental oxygen/respiratory support, presence of fever). Once the patient has been "clinically stable" x48 hours, antibiotics will be discontinued.
干预措施: Clinical Stability Assessment (Other)
结局指标
主要结局
Proportion of eligible patients who consent to participate in the intervention
时间窗: 48 hours
Caregiver and medical provider acceptability
Rate of persistent and worsening respiratory symptoms measured by patient's clinical status; the rate of emergency department revisit or hospital readmission within 1 week of antibiotic discontinuation
时间窗: 1 week
Patient Safety Outcomes
次要结局
- Median days of antibiotics received for patients in the intervention group as well as from historical control group(30 days)
研究者
Kathleen Snow
Instructor, Pediatrics
Boston Children's Hospital