Comparing VO2 Peak Values of Exercise Testing Protocols for Females and Males With CAD
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 54
- 试验地点
- 1
- 主要终点
- Oxygen Consumption (VO2)
研究概览
简要总结
The aim of this study is to determine if the test that allows males to achieve a higher VO2 (a measure of oxygen use during exercise) is different for females. The purpose of this study is to test 4 different exercise testing protocols to compare measured oxygen consumption in females and males with CAD (disease caused by the buildup of plaque in the artery walls which can lead to insufficient amounts of blood, nutrients and oxygen being supplied to the heart). The 4 exercise tests that will be completed on the treadmill are the modified Balke, modified Bruce, modified Naughton and University of Ottawa Heart Institute Slow Ramp protocols. Each test has a different stage duration (the amount of time that the test remains at a pre-determined speed and incline), and incremental increase in speed and incline.
The main purpose of this study is to compare VO2 peak (the maximal amount of oxygen utilized during the exercise test) of females and males with CAD in 4 different exercise protocols. For example, the investigators will find out:
- which exercise protocol is more likely to achieve a higher peak V̇O2 in females and which protocol is more likely to achieve a higher peak V̇O2 in males,
- if enjoyment affects the duration of the test, and
- how different exercise test protocols will provide different results of maximal oxygen used by the participant's body during the exercise test.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18 years and older;
- •previous CAD diagnosis by a physician;
- •can perform a CPET until volitional exhaustion;
- •are able to self-ambulate on a treadmill;
- •are at least 8 weeks post cardiovascular event or procedure (i.e., percutaneous coronary intervention (PCI), coronary artery bypass graft (CABG)); and,
- •are able to provide written informed consent.
排除标准
- •cannot speak, read, write, or understand English or French;
- •currently not enrolled in a CR program;
- •have recently changed (or planning to change) PA levels within the previous 4 weeks (as this may impact the ability to compare outcomes between exercise testing protocols);
- •have heart failure with an ejection fraction <45% (indication of possible cardiomyopathy);6
- •have an arrythmia (relative contraindication for exercise testing),6 peripheral artery disease, valvular disease, severe aortic stenosis, cardiomyopathy, SCAD and/or COPD (contraindications for maximal exercise testing);
- •has an ICD;
- •is pregnant (sustained vigorous exercise in pregnant women may induce fetal bradycardia)
- •is unable to complete submaximal exercise testing (i.e., treadmill, due to musculoskeletal limitations).
研究组 & 干预措施
CPETs
Patients will perform all 4 maximal cardiopulmonary exercise tests in randomized order. The protocols they will perform are: Modified Bruce, modified Naughton, modified Balke and the UOHI Slow Ramp.
干预措施: Exercise Tests (Diagnostic Test)
结局指标
主要结局
Oxygen Consumption (VO2)
时间窗: Week 1 to week 4 (measured weekly, at every appointment)
V̇O2 will be measured continuously throughout the treadmill CPET. Peak V̇O2, defined as the highest V̇O2 value that is achieved over a 20-s period during the last minute of the CPET. V̇O2 will be measured throughout each test by a metabolic system (Parvo Medics TrueOne 2400).
次要结局
- Cardiometabolic health indicators - Waist circumference(Week 1 to week 4 (measured weekly, at every appointment))
- Cardiometabolic health indicators - Height(Week 1 to week 4 (measured weekly, at every appointment))
- Reason for test termination(Week 1 to week 4 (collected weekly, at every appointment))
- Cardiometabolic health indicators - Fat mass(Week 1 to week 4 (measured weekly, at every appointment))
- Blood Lactate(Week 1 to week 4 (measured weekly, at every appointment))
- Physical activity enjoyment(Week 1 to week 4 (collected weekly, at every appointment))
- Cardiometabolic health indicators - Body mass index(Week 1 to week 4 (measured weekly, at every appointment))
- Rating of perceived exertion (RPE)(Week 1 to week 4 (measured weekly, at every appointment))
- Test duration(Week 1 to week 4 (measured weekly, at every appointment))
- Cardiometabolic health indicators - Blood pressure (BP)(Week 1 to week 4 (measured weekly, at every appointment))
- Cardiometabolic health indicators - Heart Rate (HR)(Week 1 to week 4 (measured weekly, at every appointment))
- Most enjoyed test(Week 4 - collected at the patient's last appointment)