Relevance of Sensitization to Fenugreek in Children
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Oral food challenge to fenugreek
研究概览
简要总结
The prevalence of allergy to legumes is inscreasing, especially in children and for some of these legumes, little is known and there are not included in the list of priority allergen. The overall goal of this study is to improve knowledge about fenugreek allergy. The principal aim is to evaluate the prevalence of allergy to fenugreek confirmed by a positive oral food challenge in children sensitized to fenugreek. The secondary objectives are to describe the case of allergy to fenugreek (co-allergies, severity, age..), to evaluate diagnostic values of skin prick-tests and specific IgE and to compare the molecular profile of specific IgE to peanut between sensitization to fenugreek without allergy and sensitization with a confirmed allergy
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 1 Year 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Children for whom an oral food challenge to fenugreek has been performed between the 1st January 2017 and the 15th April 2022 and for whom skin prick test and/or specific IgE to fenugreek are avalaible
排除标准
- •patient over 18 years old
- •undeterminate oral food challenge
结局指标
主要结局
Oral food challenge to fenugreek
时间窗: 2017-2022
Astier's score 0 to 4 (0=negative, 1 and 2=mild to moderate reaction, 3 and 4 = severe reaction)
skin prick-test to fenugreek
时间窗: 2017-2022
skin prick test positive if wheal size superior to 3mm
specific IgE to fenugreek
时间窗: 2017-2022
specific IgE positive if value superior to 0.35kU/L
次要结局
- severity of allergy(2017-2022)
- molecular profile for peanut allergy(2017-2022)
研究者
Amandine DIVARET-CHAUVEAU
Head of pediatric allergy department
Central Hospital, Nancy, France