NCT02896608已完成不适用
Neuronal Excitability of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN1) Channel Mutations in Dravet Syndrome
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 92
- 试验地点
- 1
- 主要终点
- hyperpolarizing electrotonus
研究概览
简要总结
This study addresses the changes in the axonal excitability parameters. It will compare these changes in patients with early infantile epileptic encephalopathy with HCN1 channel mutation and in control patients, with and without epilepsy.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 15 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •early infantile epileptic encephalopathy with HCN1 channel mutation
- •control patients with no neurologic pathology (age, gender and body temperature matched)
- •epileptic patients (age, gender and body temperature matched)
排除标准
- •pregnant or breast feeding patient
结局指标
主要结局
hyperpolarizing electrotonus
时间窗: baseline
hyperpolarizing threshold current
时间窗: baseline
次要结局
未报告次要终点
研究者
研究点 (1)
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