NCT03423693已完成不适用
Comparative Study on Sputum Anti-inflammatory Mediators in Patients With Asthma or Asthma and COPD Overlap (ACOS) Syndrome, and COPD
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 230
- 试验地点
- 1
- 主要终点
- Lipoxin A4, ,
研究概览
简要总结
This study was designed as retrospective chart review to test our hypothesis whether there are the differences in inflammatory and anti-inflammatory mediators between asthmatic and ACOS patients with small airway obstruction, and COPD
详细描述
The data including spirometry, lung volume, impulse oscillometry, sputum data, demographic characters within 6 months are collected for later analysis. Sputum supernatants and cytospins are used to determine inflammatory and anti-inflammatory responses in those patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Physician-diagnosed asthma, ACO, and COPD
- •Their spirometric, IOS, lung volume, demographic data and sputum samples are available
排除标准
- •Concomitant diseases requiring immunosuppressive therapy
- •Being on treatments with NSAIDs, macrolides, statins
结局指标
主要结局
Lipoxin A4, ,
时间窗: 1 day (single time point)
Lipoxin A4 is measured in sputum supernatants by ELISA
次要结局
- IL-33(1 day (single time point))
- Thymic stromal lymphopoietin (TSLP)(1 day (single time point))
研究者
Kittipong Maneechotesuwan
Professor
Mahidol University
研究点 (1)
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