NCT01044615已完成不适用
Advanced Imaging Tools in the Study of Mild Traumatic Brain Injury
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
研究概览
简要总结
We will utilize a set of imaging modalities including computed tomography (CT), positron emission tomography (PET), and a suite of magnetic resonance imaging (MRI) tools, to investigate the changes in the human brain resulting from mild traumatic brain injury (mTBI).
详细描述
We will recruit mTBI subjects and control subjects. Each subject will undergo the set of imaging modalities, and the results will be analyzed for differences at the structural, physiological, and molecular levels. The long term goal of this research is the development of a method to diagnose mTBI based on physical markers. This is a phased project beginning with a pilot study followed by future studies with larger sample sizes.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Study group:
- •Between 18 and 55 years of age inclusive.
- •Potential participant verbally verifies diagnosis of mTBI at pre-screen.
- •Diagnosed with mild traumatic brain injury by a VAMC physician according to standard diagnostic criteria [12],[13], to be verified by chart review.
- •Less than 24 months from trauma resulting in mTBI.
- •Able to read and write in English.
- •Willingness to refrain from nicotine, and beverages containing either alcohol or caffeine for at least four hours prior to the imaging session.
- •Have signed the consent form for the study.
- •Control Group:
- •Between 18 and 55 years of age inclusive.
- •Potential participant verbally denies history of mTBI at pre-screen.
- •Able to read and write in English.
- •Willingness to refrain from nicotine, and beverages containing either alcohol or caffeine for at least four hours prior to the imaging session.
- •Have signed the consent form for the study
排除标准
- •Conditions that would preclude the completion of a MRI, PET, or CT exam such as claustrophobia, pacemaker, metal objects in body, and/or pregnancy.
- •Serious, unstable medical or mental illness.
- •Medical contraindication to any element of the study procedure.
- •Have not read and signed an informed consent form, or do not understand its contents.
研究者
研究点 (1)
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