Low-dose Buprenorphine as a Modulator of Social Motivation in Schizophrenia
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Attention bias
研究概览
简要总结
Low social motivation is a significant symptom of schizophrenia and is a major cause of disability and suffering for many patients struggling with the illness. Social motivation refers to the drive to participate in or abstain from social activities. Many patients with schizophrenia evidence both decreased drive to seek positive social input (approach motivation) and heightened drive to avoid negative social input (avoidance motivation) compared to individuals without the illness. Despite the enormous burden of these deficits on patients, there are no medications that effectively treat impaired social motivation. Buprenorphine is an unusual drug that is used to treat opioid use disorder at higher doses and more recently, to treat depression and suicidality at lower doses. It is a unique opioid medication that has a compound action that gives it the potential to improve social motivation both by boosting approach motivation and by reducing avoidance motivation. The effects of low doses of buprenorphine have previously. been studied in healthy volunteers, showing that the drug enhances social motivation. These results in nonclinical volunteers suggest that buprenorphine may be a promising treatment for deficits in social motivation seen in some patients with schizophrenia. However, no previous studies have investigated the effects of buprenorphine on social motivation in this population. Here the effects of a low dose of buprenorphine (0.15mg) on social motivation in patients with schizophrenia (N=40) will be assessed. In this double-blind, cross-over, placebo-controlled study, participants will attend a 2-hour preparatory session and two 6-hour laboratory sessions, at which they will receive either placebo or buprenorphine. During expected peak drug effect they will complete validated tasks assessing social motivation. It is expected that buprenorphine will increase approach motivation and decrease avoidance motivation as measured by an attention bias task. The results of this study will lay the foundation for the clinical use of buprenorphine as the first medication to treat social deficits in schizophrenia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •able to understand spoken English sufficiently to comprehend testing procedures
- •score below the mean of participants screened previously screened on the Lubben Social Network Scale
- •DSM-5 diagnosis of schizophrenia
- •clinical stability (i.e., no inpatient hospitalizations for six months prior to enrollment, no changes in medication in for 6 months prior to enrollment, no current positive symptoms greater than moderate)
- •c) no history of IQ less than 70 or developmental disability, based on medical history d) no current use of opioid medication e) no clinically significant neurological disease (e.g., epilepsy), cardiovascular condition (e.g. cardiac arrhythmia), or respiratory condition (e.g., asthma) based on medical history
- •no history of serious head injury (i.e., loss of consciousness longer than 1 hour, neuropsychological sequelae, cognitive rehabilitation treatment after head injury) based on medical history
- •no substance or alcohol use disorder in the past six months, or history of opioid use disorder
- •no sedatives, benzodiazepines within 24 hours of testing
- •no positive urine toxicology screen or visible intoxication on the day of assessment
- •no women who are pregnant or think that they might be pregnant, based on self-report and urine test
排除标准
- 未提供
研究组 & 干预措施
Buprenorphine, placebo
One group will receive buprenorphine (0.15mg) first, then placebo.
干预措施: Placebo (Drug)
Placebo, buprenorphine
One group will receive placebo first, then buprenorphine (0.15mg).
干预措施: Placebo (Drug)
Placebo, buprenorphine
One group will receive placebo first, then buprenorphine (0.15mg).
干预措施: Buprenorphine 0.15 MG [Belbuca] (Drug)
Buprenorphine, placebo
One group will receive buprenorphine (0.15mg) first, then placebo.
干预措施: Buprenorphine 0.15 MG [Belbuca] (Drug)
结局指标
主要结局
Attention bias
时间窗: 90 minutes after drug administration
Number of gazes toward each stimulus type on the attention bias task.
次要结局
未报告次要终点
研究者
Anya Bershad, MD, PhD
Resident Physician
University of California, Los Angeles