Urine Levels of Metanephrin and Normetanephrin in Patients With Frequent Ventricular Premature Complex
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- metanephrine and normetanephrine levels
研究概览
简要总结
Enhanced automaticity process is the underlying mechanism for arrhythmias due to excess catecholamines. Catecholamines may increase in patients with PVC. Metabolites of catecholamines are metanephrine and normetanephrine. Our aim is to measure 24 hours urine levels of metanephrine and normetanephrine.
详细描述
Premature ventricular complex is a very frequent arrhythmia. Suggested mechanisms for PVCs are reentry, triggered activity, and enhanced automaticity. Enhanced automaticity process is the underlying mechanism for arrhythmias due to excess catecholamines. Catecholamines may increase in patients with PVC. Half-lives of catecholamines are very short and rather changeable. Therefore, 24 hours urine levels of catecholamines are the more sensitive than plasma levels. Metabolites of catecholamines are metanephrine and normetanephrine. Our aim is to measure 24 hours urine levels of metanephrine and normetanephrine.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •PVC's rate is more than % 5 in 24 hours rhythm recording
排除标准
- •ischemic heart disease
- •hyperthyroidism
- •patients with low ejection fraction
结局指标
主要结局
metanephrine and normetanephrine levels
时间窗: about 10 months
metanephrine and normetanephrine levels asociated premature ventricular complex frequents
次要结局
未报告次要终点
研究者
Burak Cesur
burak cesur
TC Erciyes University