If Heart Rate Variability Can Predict Continuous Positive Airway Pressure Acceptance and Compliance for Patients With Obstructive Sleep Apnea ?
试验速览
- 阶段
- 不适用
- 入组人数
- 192
- 试验地点
- 2
- 主要终点
- If changes in LF/HF ratio (Low frequency/High frequency ratio) could be a valuable predictor for CPAP acceptance in OSA patients?
研究概览
简要总结
This study aim to evaluate if the improvement of heart rate variability for the continuous positive airway pressure titration night can predict the short and long term continuous positive airway pressure adherence for patients with moderate to severe OSA.
详细描述
Heart rate variability (HRV) represents autonomic regulation and had been used in varies situation, especially the associated with cardiovascular outcomes and psychological diseases. HRV was also well known associated with the severity of obstructive sleep apnea (OSA) and could be improved after adequate treatments for OSA. Continuous positive airway pressure (CPAP) is the first choice of treatment for OSA and had been proved to able to improve HRV in OSA patients. However, the CPAP adherence is always problematic. Many CPAP predictors had been well documented but the HRV is never evaluated to be a potential predictor of CPAP adherence.
Therefore, this study will evaluate the changes of HRV for polysomnography (PSG) night, for CPAP titration night to see if the changes of HRV in the CPAP titration night could predict CPAP adherence for OSA patients in Taiwan.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •aged:20~75y/o
- •PSG revealed moderate to severe OSA (apnea hypopnea index [AHI] ≧15/hour)
- •had been completed CPAP titration test
排除标准
- •aged<20y/o or >75 y/o
- •mild OSA, (AHI <15/hour), or no OSA (AHI<5/hour)
- •unstable cardiopulmonary disease, psychological diseases, using sleep pills.
结局指标
主要结局
If changes in LF/HF ratio (Low frequency/High frequency ratio) could be a valuable predictor for CPAP acceptance in OSA patients?
时间窗: 1 month
Changes of LF/HF ratio between PSG study night and CPAP titration night will be measured and evaluated its association with CPAP acceptance of one month CPAP trial at home in moderate to severe OSA patients.
次要结局
- If CPAP treatment could improve LF/HF ratio after 6 months of treatment in moderate to severe OSA patients?(6 months)
研究者
Mei-Chen Yang
Attending physician
Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation