Quantitative Analysis Between Neuromuscular Blocking Agent and Motor Evoked Potential and Analysis of Risk Factors for the Coefficient of Variance of Motor Evoked Potential in Patients Undergoing Brain Tumor Removal Surgery: Population Approach
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Amplitude of the motor evoked potential
研究概览
简要总结
It is important to predict the influence of the neuromuscular blocking agents on the motor evoked potential. Investigator will investigate the dose-response relationship between the degree of the neuromuscular blockade and the motor evoked potential in patients undergoing brain tumor surgery using the population approach. Investigator will investigate the influence of the other factors such as the impedence, reactance, muscel amount, and age on the motor evoked potential.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged 19 years old or older, with American Society of Anesthesiologists Physical Status 1-3, and scheduled for elective brain tumor surgery under the monitoring of the motor evoked potential
排除标准
- •Central or peripheral neuromuscular disease
- •Sensory or motor nerve disorder
- •Allergy to propofol, remifentanil, and rocuronium
- •Patients with pacemaker
研究组 & 干预措施
rocuronium
Neuromuscular blockade will be performed using rocuronium.
干预措施: Arm I (MEP) (Drug)
结局指标
主要结局
Amplitude of the motor evoked potential
时间窗: At intraoperative 0 hr from the start of the anesthetic induction
Amplitude of the motor evoked potential will be evaluated at intraoperative 0 h from the start of the anesthetic induction.
次要结局
- Amplitude of the motor evoked potential(At intraoperative 0 h from the opening of the dura)
研究者
Dong Woo Han
Professor
Gangnam Severance Hospital