Comparison of effect of topical application of argyreia speciosa gel and non-eugenol periodontal dressing on tissue response, wound healing, and pain following periodontal flap surgery – a split mouth randomized clinical study

Aim of this study is to comparison of effect of topical application of argyreia speciosa gel and non-eugenol periodontal dressing on tissue response, wound healing, and pain following periodontal flap surgery – a split mouth randomized clinical study. After obtaining thorough case history and written informed consent from the patients enrolled in the study (considering all inclusion and exclusion criteria) each patient would undergo the required periodontal flap surgery. After the surgical procedure, randomisation and quadrant allotment for either Topical application of Argyreia speciosa gel or non-eugenol periodontal dressing will be done. For periodontal dressing group, COE-PAK will be mixed and applied, according to manufacturer instructions. For Argyreia speciosa gel group, Argyreia speciosa gel will be applied immediately by the clinician and also will be given to the patient to apply as directed on the operated site twice daily for the next 7 days. Patients failing to comply with timely application of Argyreia speciosa gel as instructed will be excluded from the study. After 1 week the pack and sutures will be removed by the same operator. Early Healing Score (EHS) after 1 week and healing index (HI) after 1st, 2nd week and VAS after 1st and 2nd week will be recorded as per the guidelines given by Lorenzo Marini et al, Landry et. al. (1988 ) and Faezeh Ghaderi et al respectively by second blinded operator.