Clinical Manifestations and Long-Term Outcome in Early Lyme Neuroborreliosis According to Diagnostic Certainty
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 311
- 试验地点
- 1
- 主要终点
- composite clinical score
研究概览
简要总结
In this retrospective cohort study of patients with early Lyme neuroborreliosis (LNB), clinical and microbiologic characteristics and long-term outcome of definite vs. possible LNB were evaluated at a single university medical center in Slovenia. Severity of acute disease and long-term outcome during a 12-month follow-up were assessed using a composite clinical score based on objective clinical findings and subjective complaints.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •early Lyme neuroborreliosis
排除标准
- •Not fulfilling study criteria for definite or possible Lyme neuroborreliosis
- •Alternative diagnosis during follow-up
- •Concomitant tick-borne encephalitis
- •Clinical symptoms/signs present for >6 months
- •Data not available
结局指标
主要结局
composite clinical score
时间窗: follow-up for 12 months-post-treatment
Composite clinical score based on objective clinical findings and subjective complaints. The sum of subjective complaints and objective findings scored as 0=absent or 1=present represent severity of disease on admission or clinical outcome at follow-up, respectively. Maximum total score=31
次要结局
未报告次要终点
研究者
Daša Stupica
Principal Investigator
University Medical Centre Ljubljana