NL-OMON44328已完成4 期
PHARMACOKINETICS OF CARBOPLATIN AFTER ADJUSTED DOSING FOR HIGH BMI, LOW SERUM CREATININE, AND MAXIMAL RENAL FUNCTION - Prospective validation of an alternative dosing algorithm of carboplatin
ziekenhuisapotheek0 个研究点目标入组 24 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 24
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- any type of histologically or cytologically proven solid tumor for which treatment with carboplatin is indicated
- •- to be treated with carboplatin with a target AUC of 4, 5 or 6
- •- age 18 years or older
- •- WHO status 0 - 2
- •- adequate bone marrow and liver function defined as
- •o haemoglobin >= 6.0 mmol/L
- •o white blood cell count >= 3.0 * 109/L
- •o absolute neutrophil count (ANC) >= 1.5 * 109/L
- •o platelets >= 100/L
- •o bilirubin <= 1.5 times ULN
- •o ALAT and ASAT <= 2.5 times ULN (in case of liver metastases <= 5.0 times ULN).
- •- estimated life expectancy of at least 12 weeks
排除标准
- •- Treatment with carboplatin with a target AUC of <4
- •- active clinically serious infection
- •- history of a kidney allograft
- •- pregnant
- •- patients not suitable for follow-up
研究者
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