Prevention of Hepatitis B Virus Mother-to-Child Transmission (MTCT) From HIV-HBV Co-infected Pregnant Women by Use of Nucleosides/Nucleotides Analogues With Dual Activity During Pregnancy.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 35
- 试验地点
- 1
- 主要终点
- Hepatitis B sAg status in children born from HIV-Hepatitis B Virus co-infected women
研究概览
简要总结
Vertical HIV transmission has been dramatically reduced by the use of combined antiretroviral therapy in HIV-infected pregnant women. Among the most often used drugs, several have dual activity, against HIV and HBV: lamivudine, emtricitabine, tenofovir. Studies about vertical HBV transmission from HIV-HBV co-infected pregnant women are rare in developed countries. The study hypothesis is a major reduction of the risk of HBV vertical transmission.
详细描述
Mother-to-Child HIV transmission has been dramatically reduced by the use of combined antiretroviral therapy in HIV-infected pregnant women, both in developed and in developing countries. Among the most often used drugs, several have dual activity, against HIV and HBV: lamivudine, emtricitabine, tenofovir; they can be used as a combo, as tenofovir+emtricitabine for instance. Studies about vertical HBV transmission from HIV-HBV co-infected pregnant women are rare in developed countries. The study hypothesis is a major reduction of the risk of HBV vertical transmission in this context, justifying this retrospective study.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 9 Months 至 15 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •children born in the Maternity Department from HIV-HBV co-infected women
- •whose mother was given a treatment with dual activity (HIV and HBV) during pregnancy
排除标准
- 未提供
结局指标
主要结局
Hepatitis B sAg status in children born from HIV-Hepatitis B Virus co-infected women
时间窗: up to 10 years (expected average: 5 years)
次要结局
- Antibodies (Ab) against Hepatitis B core antigen in children(up to 10 years (expected average: 5 years))
研究者
Célia Lloret-Linares, MD PhD
Professor at Paris VII Denis Diderot University, physician
Hopital Lariboisière