The Effect of Cognitive Functions on Upper Extremity Functionality in Parkinson's Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 104
- 试验地点
- 1
- 主要终点
- Modified Hoehn Yahr Scale
研究概览
简要总结
Parkinson's Disease (PD), first described by James Parkinson in 1817, is a progressive movement disorder that develops mainly as a result of the destruction of nigrostriatal dopaminergic neurons. The aim of our study is to determine the effect of cognitive functions on upper extremity functionality in individuals with Parkinson's Disease.
详细描述
Parkinson's Disease (PD), first described by James Parkinson in 1817, is a progressive movement disorder that develops mainly as a result of the destruction of nigrostriatal dopaminergic neurons. Involvement of nigrostriatal dopaminergic neurons is associated with the motor manifestations of the disease. The most common of these symptoms are; resting tremor, bradykinesia, rigidity and balance disorder. However, non-motor symptoms related to the involvement of nervous system structures other than the dopaminergic nigrostriatal system can be observed in PD. However, due to the predominance of motor symptoms in PD, it took many years to notice cognitive changes. Traditionally, cognitive impairments in PD have been expected to occur in the advanced stages of the disease. However, cognitive impairments in the early stages are reported in approximately 30-35% of patients. Cognitive dysfunction is defined in PD, ranging from mild impairments in certain cognitive domains to severe dementia. Cognitive impairment primarily affects executive and visuospatial functions, and memory is secondarily affected.
Executive functions are higher cognitive processes that use and modify information from many cortical sensory systems in the fore and hindbrain areas to modulate and teach behavior. The frontal cortex, especially the prefrontal cortex and its striatal connections are very important neuroanatomical regions for executive functions. The relationship between the effects of cognition and motor performance and parameters in groups such as the elderly, PD and Alzheimer's patients in which these centers are affected has been an issue that has attracted the attention of many researchers. Most of the studies have focused on the lower extremity performance of cognition. However , it has been reported that cognition has positive effects on upper extremity performance and early acquired upper extremity skills have positive effects on cognitive performance .
The aim of our study is to determine the effect of cognitive functions on upper extremity functionality in individuals with Parkinson's Disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Having a diagnosis of Parkinson's Disease.
- •Not having hearing and vision problems.
- •To be able to take the commands required for the manual dexterity tests.
- •Agree to participate in the study.
排除标准
- •Having undergone musculoskeletal surgery for the upper extremity.
- •Having vision and hearing problems.
- •Having an additional disease that may affect cognitive tests.
研究组 & 干预措施
patient group
parkınson patient group
干预措施: clinical assessment (Diagnostic Test)
healthy group
age-gender matched healthy group
干预措施: clinical assessment (Diagnostic Test)
结局指标
主要结局
Modified Hoehn Yahr Scale
时间窗: 1 year
Used for clinical staging of Parkinson's disease
Unified Parkinson's Disease Rating Scale
时间窗: 1 year
Used for the evaluation of clinical manifestations of Parkinson's disease
Parkinson's Disease Questionnaire-PDQ 39
时间窗: 1 year
Used to assess the quality of life of Parkinson's patients
次要结局
- Dexterity Questionnaire-24(1 year)
- Wechsler Memory Scale-Revised(1 year)
- Nine Hole Peg Test(1 year)
- Stroop Test(1 year)
研究者
Dudu ŞİMŞEK
MSc Physiotherapist
Pamukkale University