Efficacy of autologous platelet-rich fibrin (PRF) over moist sterile saline dressing in chronic trophic ulcers in Hansenâ??s disease patients â?? a Randomised Control Trial.

JAWAHARLAL INSTITUTE OF POSTGRADUATE MEDICAL EDUCATION AND RESEARCH0 个研究点目标入组 66 人开始时间: 待定最近更新: 2021年11月24日

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•Patients with Hansenâ??s disease who have chronic trophic ulcers of lower extremity of > 6 months duration, attending the dermatology out-patient department in JIPMER, having an ulcer area of 1cm x 1cm to 5cm x 5 cm, and belonging to stage II or stage III of the European Pressure Ulcer Advisory Panel (EPUAP) scheme

•Ulcers < 6 months duration.
•Ulcers of other etiology e.g. venous ulcer/arterial ulcer/diabetic ulcer/ulcer with underlying vasculitis.
•Patients with osteomyelitis affecting the area of the ulcer.
•Ulcers with exposure of tendons or bones.
•Ulcers with area <1cm x 1cm or > 5cm x 5cm
•Ulcers with copious discharge /overt infection /infected with Pseudomonas.
•Patients with HIV/ HBsAg/ HCV
•Hemoglobin < 11 gm/dl and/or platelet count < 1,50,000/ mm3
•Serum albumin < 4.5 mg/dl
•Patients with malignancy/ uncontrolled diabetes mellitus/received radiation therapy/on drugs like steroids, immunosuppressive agents/compromised cardiopulmonary status/ compromised endocrine status/ acid-base imbalance/ renal failure/ liver failure/ any other factor impairing wound healing.
•Patients receiving anti-coagulants/ anti-platelet drugs/ bleeding diathesis
•Patients with age < 18 years or > 65 years
•Pregnancy and lactation
•Non-consenting patients

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