EEG Patterns in Patients With Acute Ischemic Stroke Resulted From Large Vessels Occlusion in the Anterior Circulation
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- EEG pattern
研究概览
简要总结
Clinical deterioration is observing in up to forty percent of patients with acute ischemic stroke (AIS) due to large vessels occlusion. Until now, there is no automated monitoring system for early detection of neurological deterioration in such patients. As a first step to develop such system investigators suggest this study aiming to evaluate patterns of brain electrical activity registered by EEG in patients with AIS attributed to the MCA or ICA territory correlated with location and extension of ischemic lesions as determined by non-contrast CT (NCT).
详细描述
Rationale. Despite the exciting developments in the treatment of acute ischemic stroke (AIS) in last years, the problem of neurological deterioration in patients with AIS remains unresolved and poorly understandable. This is especially correct about patients with AIS resulted from large vessel occlusion (LVO), mainly internal carotid artery (ICA) and middle cerebral artery (MCA) occlusion. Such deterioration is observing in up to forty percent of patients with acute ischemic stroke due to LVO. On the other side, according to the literature about 40 % of LVO strokes resulted from atrial fibrillation. Until now, there is no automated monitoring system for early detection of neurological deterioration in AIS patients. Such monitoring system may save millions of lives of stroke victims all over the world. As a first step to develop such system based on change of brain electrical activity registered by electroencephalography (EEG) in patients with AIS investigators suggest this study.
Overall goal. The aim of the suggested research is to evaluate patterns of brain electrical activity registered by EEG in patients with AIS attributed to the MCA or ICA territory in correlation with location and extension of ischemic lesions as determined by non-contrast CT (NCT). Based on these data, the attempt to find algorithms, describing such correlation will be done.
Target population. The prospective study will include at least 200 AIS patients with acute stroke resulted from MCA or ICA occlusion.
Methods. Non contrast CT and EEG will be done at the same day. Neurologist will evaluate neurological status at the day of EEG and CT performing and clinical score by National Institute of Health Stroke Scale (NIHSS) will be obtained. EEG will be performed continuously for at least 30 minutes with 19-channel EEG machine.
Assessment. After gathering clinical, EEG and NCT data mathematical and computerized analysis (including Artificial Intelligence methods) will be applied aiming to find algorithms describing relationship between size and location of AIS and change in brain electrical activity registered by EEG in AIS patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with acute ischemic stroke, due to large vessel occlusion
- •Age of 18 years and more
- •Male or Female
- •Modified Rankin Scale of ≤ 2 prior to presentation
- •NIHSS ≥ 4 at the day of NCT and EEG
排除标准
- •Brainstem or cerebellar stroke
- •Intracranial or extracranial hemorrhage of any kind
- •History of severe head trauma
- •History of severe dementia or progressive neurodegenerative disease
- •Cerebral tumor or hydrocephalus by anamnesis or by imaging
- •Lacunar stroke
- •Significant movement disorder.
- •Local skull or skin condition, preventing EEG electrode application.
- •Any known disorder, which may interfere with the protocol implementation.
研究组 & 干预措施
patients with acute ischemic stroke
This open-label prospective study will be conducted in the single medical center (RAMBAM Medical Center) and will include at least 200 patients with acute ischemic stroke resulted from MCA or ICA occlusion.
干预措施: Electroencephalography (EEG) (Diagnostic Test)
结局指标
主要结局
EEG pattern
时间窗: 24 months
EEG patterns depending on size and location of acute ischemic stroke,including generalized or focal slowing or both and epileptiform discharges
次要结局
未报告次要终点
研究者
rambam62
Director, Head of Stroke Service, Principal Investigator, Clinical Professor
Rambam Health Care Campus