Avoiding High PEEP in COVID-19 Induced ARDS: a Multi-center Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Respiratory system compliance improvement
研究概览
简要总结
This was a multi-center prospective study. All consecutive severe cases of COVID-19 whose PO2/FiO2<300mmHg with invasive ventilation admitted to 5 fixed-point receive COVID-19 patients hospitals in Wuhan from 5 March to 15 March 2020 were included. Epidemiological, clinical data, lung mechanics, artery blood gas test and hemodynamics at three methods to titrate PEEP, optimizing oxygenation, optimizing compliance, ARDSnet. The study was approved by the Ethics Committee of Zhongda Hsopital, Southeast University.
详细描述
After PEEP titration, PEEP settings could be set by optimizing oxygenation, optimizing compliance, ARDSnet.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •COVID-19 patients with mechanical ventilation
- •PO2/FIO2<300mmHg
- •ages>18 years
排除标准
- •pneumothorax
- •hemodynamics is unstable
结局指标
主要结局
Respiratory system compliance improvement
时间窗: 20 minutes
the respiratory system compliance was compared among three groups
次要结局
- Gas echanges improvement(20 minutes)
研究者
Chun Pan
Dr
Southeast University, China