A Phase 2 Study of AZD2171 in Patients With Advanced Renal Cell Carcinoma
试验速览
- 阶段
- 2 期
- 状态
- 终止
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Objective Response
研究概览
简要总结
This phase II trial is studying how well AZD2171 works in treating patients with refractory metastatic kidney cancer. AZD2171 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
详细描述
PRIMARY OBJECTIVES:
I. Determine the objective response rate in patients with refractory metastatic renal cell carcinoma treated with AZD2171.
SECONDARY OBJECTIVES:
I. Determine the safety and tolerability of AZD2171 in these patients. II. Determine the feasibility of performing standardized delayed contrast-enhancement-MRI correlative studies across different institutions and platforms with data-sharing capability in patients with metastatic renal cell cancer.
III. Generate preliminary data regarding potential utility of pharmacogenomic and plasma/serum biomarkers of angiogenesis as predictive or prognostic markers for future investigations of AZD2171 and renal cell carcinoma.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Histologically or cytologically confirmed clear cell renal cell cancer
- •Must be predominantly metastatic disease
- •Refractory disease
- •Measurable disease, defined as ≥ 1 unidimensionally measurable lesion ≥ 20 mmby conventional techniques or ≥ 10 mm by spiral CT scan
- •No known brain metastases
- •ECOG performance status 0-2
- •Karnofsky 60-100%
- •WBC ≥ 3,000/mm^3
- •Absolute neutrophil count ≥ 1,500/mm^3
- •Platelet count ≥ 100,000/mm^3
- •Hemoglobin ≥ 8.0 g/dL
- •AST and ALT ≤ 2.5 times upper limit of normal (ULN)
- •Bilirubin normal
- •Creatinine normal OR creatinine clearance > 60 mL/min
- •Blood pressure < 140/90 mm Hg on 2 separate occasions not more than 6 weeks prior to enrollment and not less than 24 hours apart (stable antihypertensive regimen allowed)
- •Mean QTc ≤ 470 msec (with Bazett's correction)
- •Less than +1 proteinuria on two consecutive dipsticks taken no less than 1 week apart
- •Not pregnant or nursing
- •Negative pregnancy test
- •Fertile patients must use effective contraception
- •No history of familial long QT syndrome
- •No cardiac arrhythmia
- •No unstable angina pectoris
- •No symptomatic congestive heart failure
- •No New York Heart Association class III or IV disease
- •No ongoing or active infection
- •No hypertension
- •No other uncontrolled intercurrent illness
- •No history of allergic reactions attributed to compounds of similar chemical or biologic composition to AZD2171
- •No psychiatric illness or social situations that would limit compliance with study requirements
- •See Disease Characteristics
- •More than 4 weeks since prior radiotherapy and recovered
- •More than 4 weeks since prior major surgery and recovered
- •More than 4 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin C) and recovered
- •More than 30 days since other prior investigational agents
- •No prior therapy with vascular endothelial growth factor (VEGF) binding agents or VEGF receptor (VEGFR) tyrosine kinase inhibitors
- •No more than 1 prior nonVEGF-directed systemic therapy for this disease
- •No concurrent medication that may markedly affect renal function (e.g., vancomycin, amphotericin, ibuprofen, pentamidine)
- •No combination antiretroviral therapy for HIV-positive patients
- •No concurrent hematopoietic growth factors except epoetin alfa and bisphosphonates
- •No concurrent hormones or other chemotherapeutic agents except for steroids given for adrenal failure and hormones administered for nondisease-related conditions (e.g. insulin for diabetes)
- •No concurrent palliative or therapeutic radiation therapy
- •No concurrent drugs or biologics with proarrhythmic potential
- •No other concurrent investigational or commercial agents or therapies to treat the patient's malignancy
排除标准
- 未提供
研究组 & 干预措施
Treatment (cediranib maleate)
Patients receive oral AZD2171 once daily for 4 weeks. Treatment repeats every 4 weeks in the absence of disease progression or unacceptable toxicity.
干预措施: cediranib maleate (Drug)
Treatment (cediranib maleate)
Patients receive oral AZD2171 once daily for 4 weeks. Treatment repeats every 4 weeks in the absence of disease progression or unacceptable toxicity.
干预措施: laboratory biomarker analysis (Other)
结局指标
主要结局
Objective Response
时间窗: Up to 6 weeks
Objective radiologic response as measured by RECIST criteria. (30% or greater shrinkage in the sum of the longest diameters of target lesions)
次要结局
- Performance of DCE_MRI(One month after initiating therapy)
- KDR(Day 28 after initiation of therapy)
- eNOS(Baseline (prior to therapy))