Clinical Study on Cardiosplenic Concurrent TreatmentMedicine for Improving the Prognosis of Complex Coronary Artery Lesions after Percutaneous Coronary Intervention

Xiyuan Hospital, China Academy of Chinese Medical Sciences0 个研究点开始时间: 待定最近更新: 2023年2月20日

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•(1) Diagnosed as complex coronary artery lesions, when coronary angiography includes at least one of the following conditions:
•a.bifurcation lesions (side branch diameter>2.0mm);
•b.excessive tortuosity of proximal segment;
•c.severe coronary artery calcification;
•d.chronic total occlusion lesions (>3 months);
•e.left main lesions;
•f.aorto-ostial lesions;
•g.diffuse lesions (>20mm length);
•h.multivessel coronary artery stenosis (=2 two vessels);
•i.extremely angulated lesions(>90°bend);
•j.in-stent restenosis.
•(2) Diagnosed as stable angina of coronary atery disease;
•(3) NYHA function grade I-?;
•(4) Within 2 years after PCI, and at least one coronary stent has been implanted;
•(5) 18 ~ 75 years old;
•(6) Diagnosed as TCM syndrome of heart and spleen deficiency;
•(7) The patient did not take antibiotics, hormones, laxatives, antidiarrheal drugs, and probiotics within 3 months before enrollment;
•(8) Written informed consent is obtained.

•(1) Indication of renal insufficiency with serum creatinine >220umo/l in men or >175umo/l in women;
•(2) Severe liver disease or ALT and AST both 3 times above the upper limit of normal;
•(3) Controlled systolic blood pressure >160 mmHg or diastolic blood pressure >100 mmHg;
•(4) Diabetic patients with random blood glucose = 13.7 mmol/L or glycosylated hemoglobin = 9.5%;
•(5) Women who are pregnant or planning to become pregnant, or who are breastfeeding;
•(6) Severe acute or chronic cerebrovascular disease;
•(7) Malignancies;
•(8) Severe hematopoietic disorders;
•(9) Severe mental illness;
•(10) Inflammatory or malabsorptive intestinal disorders;
•(11) Patients who have participated within the last three months or are participating in other clinical trials;

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