Empowering and Transforming the US Broiler Production for Growth, Profit and Sustainability
试验速览
- 阶段
- 不适用
- 状态
- 进行中(未招募)
- 入组人数
- 84
- 试验地点
- 1
- 主要终点
- Concentration of plasma DHA concentrations
研究概览
简要总结
The purpose of the research is to evaluate if chicken or eggs obtained from chickens that are fed a diet that contains omega-3 fatty acids (DHA/EPA), or vitamin D (as 25(OH)D) provides additional health benefits by improving the status of omega-3 fatty acids or 25(OH)D in healthy adults who eat this bioenhanced chicken or eggs.
详细描述
The 2015-2020 Dietary Guidelines advocate intake of lean proteins (such as chicken and fish) while limiting intake of saturated fat. Chicken contains similar protein to beef or pork but has less saturated fat. However, chicken, like other terrestrial meats, has little omega-3 polyunsaturated fatty acids such as docosahexaenoic acid (DHA) or eicosapentaenoic acid (EPA) and relatively little vitamin D. Vitamin D insufficiency is common in the US and globally, and has been linked to a number of adverse health outcomes. Vitamin D is ingested primarily from fortified dairy products, but recent animal studies have increased the D content of pork and beef, and the DHA content of chicken and of eggs produced from bioenhanced chickens. Moreover, sunlight exposure alone can enhance the 25(OH)D content of chicken. Notably, supplemental 25(OH)D is more effective than vitamin D at improving vitamin D status in humans, but little is known about the bioavailability of 25(OH)D or DHA/EPA enhanced chicken (muscle) or in enhanced eggs produced from supplemented chickens.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 35 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy adults
- •Non-smoking
- •Age between 18- 35 yo
- •Females: premenopausal and not pregnant or lactating
- •Body mass index (BMI) between 18 - 30 kg/m
- •No preexisting medical complications (such as eating disorders, gastrointestinal disorders, malabsorption diseases, or taking medications known to influence iron homeostasis)
排除标准
- •BMI <18 or > 30 kg/m2,
- •Age <18 y or > 50y,
- •Pregnancy, lactating
- •Have gastrointestinal disorders/malabsorption diseases/dietary restrictions/medication use of medications known to impact DHA/EPA or Vitamin D 25(OH)D absorption
- •Take vitamin and mineral supplementations
结局指标
主要结局
Concentration of plasma DHA concentrations
时间窗: Baseline, and time course of 1 hour, 2 hour, 4 hour and 8 hour post meal
Measuring plasma DHA concentration across different time points to assess DHA bioavailability and absorption
Concentrations of serum 25(OH)D, vitamin D2, vitamin D3, 1,25(OH)2D and 24,25(OH)2D3 and vitamin D binding protein
时间窗: Baseline, and time course of week 2, week 4, week 6, week 8
Measuring serum 25(OH)D concentration across different time points to assess 25(OH)D bioavailability and absorption
次要结局
未报告次要终点
