The Impact of Continuous Versus Intermittent Feeding on Changes in Insulin Sensitivity During Bed-rest
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Change in insulin sensitivity (measured as glucose infusion rate during hyperinsulinaemic-euglycaemic clamp)
研究概览
简要总结
In the present study, the investigators will assess the impact of two different feeding patterns (continuous vs intermittent) on insulin sensitivity and muscle mass following bedrest.
详细描述
In the present study, the investigators will assess the impact of two different feeding patterns on insulin sensitivity and muscle mass following bedrest. Healthy, young males will be fed in a continuous (no breaks in food supply) or intermittent (in boluses throughout the day) manner.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •BMI between 18.5 and 35
- •Recreationally active
排除标准
- •Type 2 diabetes
- •Performing progressive resistance training in 6 months prior to study
- •Back/knee/leg problems
- •Hypertension
- •Use of certain anticoagulants
- •All co morbidities interacting with mobility and muscle metabolism of the lower limbs
- •Blood donation in past 3 months
研究组 & 干预措施
Intermittent feeding
Intermittent feeding pattern throughout the bedrest period, with 4 boluses per day
干预措施: Intermittent feeding pattern (Other)
Continuous feeding
Continuous feeding pattern throughout the bedrest period, with 4 boluses per day, without breaks in food supply.
干预措施: Continuous feeding pattern (Other)
结局指标
主要结局
Change in insulin sensitivity (measured as glucose infusion rate during hyperinsulinaemic-euglycaemic clamp)
时间窗: 7 days bedrest
次要结局
- Change in muscle mass (measured as upper leg muscle cross-sectional area with CT scan)(7 days bedrest)
- Change in lean tissue (measured via DEXA scan)(7 days bedrest)