Core Semantic Systems of the Human Brain
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 36
- 试验地点
- 2
- 主要终点
- Mean reaction time changes in lexical decision from TMS at 150 ms
研究概览
简要总结
This study examines the time course of activation of the left anterior temporal lobe (ATL) during lexical processing using Transcranial Magnetic Stimulation (TMS).
详细描述
This study investigates the activation time of the anterior temporal lobe (ATL) region during lexical processing. Participants will perform three tasks: lexical decision, semantic decision (divided into noun and verb semantic decision), and number judgment.
Lexical Decision Task: Participants will be shown words and pseudowords (e.g., excaid). Participants have to decide if the presented stimulus is a real word or a pseudoword.
Semantic Decision Task: Participants will determine if the stimulus word refers to an action or an object that can be manipulated using the hand or arm.
Half of the stimuli will be nouns, constituting the first semantic decision task with objects, and the other half will be verbs, constituting the second semantic decision task with actions.
Number Judgment Task: Participants will decide if a presented number was divisible by four (e.g., 64) or not (e.g., 69). The stimuli will include numbers with either two or three digits.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participants must be within the ages of 18 to 40
- •Native speakers of English
排除标准
- •Potential participants with a clinically reported history of dementia, alcohol abuse, psychiatric or neurological disorders, traumatic brain injury, or extensive vision or hearing problems that prevents them from performing the tasks
- •Contraindication to TMS, determined by a standard TMS screening form
- •Contraindication to MRI, determined by a standard MRI screening form
- •Left handed participants
结局指标
主要结局
Mean reaction time changes in lexical decision from TMS at 150 ms
时间窗: Through study completion, an average of 1 year.
An interaction between time point (-100, 150) and task (lexical decision, number judgment) RT at the group level (one tailed). (LD_150 - LD_-100) - (NJ_150 - NJ_-100).
次要结局
- Mean reaction time changes in semantic decision from TMS at 150 ms(Through study completion, an average of 1 year.)
研究者
Rutvik H. Desai
Professor
University of South Carolina