Xuebijing Injection Regulates Endothelial Cell Panapoptosis in Treating Sepsis Through PCDHAC2/BAX/AIM2 Pathway
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 30
- 主要终点
- Single-cell transcriptomic analysis of inflammatory and metabolic gene expression, measured using scRNA-seq, with data summarized as differential expression profiles.
研究概览
简要总结
Sepsis is a life-threatening clinical syndrome of organ dysfunction caused by dysregulation of the body's response to infection, and is a common cause of ICU admission for critically ill patients, posing a serious threat to human health. The study demonstrated that hemopexin injection significantly reduced the 28-day all-cause mortality rate of sepsis patients, and this study clarified the specific target and molecular mechanism of hemopexin injection in the treatment of sepsis, which may be of great scientific significance and clinical value for the precise treatment of sepsis and the research and development of new drugs.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Meeting the Sepsis 3.0 diagnostic criteria;
- •SOFA score ≥ 2 and < 13;
- •Signed informed consent.
排除标准
- •Age <18 years or >75 years;
- •Pregnant or lactating women;
- •Presence of severe primary diseases including malignant tumors severe hematologic disorders and HIV infection;
- •Current use of immunosuppressants or history of organ transplantation within the past 6 months;
- •Comorbidities that significantly affect vascular endothelial structure and function such as acute myocardial infarction.
结局指标
主要结局
Single-cell transcriptomic analysis of inflammatory and metabolic gene expression, measured using scRNA-seq, with data summarized as differential expression profiles.
时间窗: Day7
Single-cell transcriptomic analysis of inflammatory and metabolic gene expression, measured using scRNA-seq, with data summarized as differential expression profiles.
次要结局
未报告次要终点
研究者
Songqiao Liu
Prof
Southeast University, China