Prospective, Double-Blinded, Randomized Head-to-Head Study of Topical Adapinoid Versus Topical Retinol
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- Facial fine lines and wrinkles
研究概览
简要总结
This study is to analyze and compare the effects of applying two topical vitamin-A derived ingredients on facial skin health, appearance and tolerability. One of these ingredients is retinol, and the other is Adapinoid, also known as Oleyl Adapalenate, a novel anti-aging ingredient.
详细描述
We want to assess the effect of applying vitamin A-derived ingredients on facial skin health, appearance, and tolerability. One of these ingredients is retinol, and the other is Adapinoid, also known as Oleyl Adapalenate.
In this study, participants will be randomized to either receiving a retinol product, or an Adapinoid product and they will be assessed at three follow up visits at week 4, week 8, and week 12.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 35 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men and women between the ages of 35 years old and 65 years old
排除标准
- •Individuals who are pregnant or breastfeeding.
- •Prisoners.
- •Adults unable to consent.
- •Individuals who have changed any of their hormonal based contraception within 3 months prior to joining the study.
- •Subjects using any topical retinoid, acetyl zingerone, vitamin C, bakuchiol, hyaluronic acid or benzoyl peroxide containing topical product within 2 weeks of starting study or any subject unwilling to refrain from washout prior to enrollment.
- •Subjects with any of the following facial cosmetic treatments in the past 3 months or those who are unwilling to withhold the following facial cosmetic treatments during study including botulinum toxin, injectable fillers, microdermabrasion, intense pulsed light (IPL), peels, laser treatments, acid treatments, facial plastic surgery, or any other medical treatment administered by a physician or skin care professional which is designed to improve the appearance of facial skin.
- •Current tobacco smoker or a tobacco smoking history of greater than 10 pack-years.
研究组 & 干预措施
Adapinoid
Product will be used once daily in the evening for 12 weeks. 1-2 pumps (size of quarter) of product will be applied on the face.
干预措施: Adapinoid (Other)
Retinol
Product will be used once daily in the evening for 12 weeks. 1-2 pumps (size of quarter) of product will be applied on the face.
干预措施: Retinol (Other)
结局指标
主要结局
Facial fine lines and wrinkles
时间窗: 12 weeks
Change in severity of fine lines and wrinkles measured by photographic analysis (BTBP 3D Camera System)
次要结局
- Facial fine lines and wrinkles(8 weeks)
- Skin redness(12 weeks)
- Facial skin pigment evenness(12 weeks)
- Self-perception of skin health and appearance(12 weeks)
- Tolerability of product(12 weeks)
- Skin redness(8 weeks)
- Facial fine lines and wrinkles(4 weeks)
- Skin redness(4 weeks)
- Facial skin pigment evenness(4 weeks)
- Facial skin pigment evenness(8 weeks)
- Self-perception of skin health and appearance(4 weeks)
- Self-perception of skin health and appearance(8 weeks)
- Tolerability of product(4 weeks)
- Tolerability of product(8 weeks)